SRP54

Protein identityUniProt · HPA

UniProt accession

P61011

Gene

SRP54

Ensembl

ENSG00000100883

Chromosome

14

Canonical length

504 aa

Protein class

Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters

Subcellular location

Cytosol

OverviewNCBI Gene

Enables several functions, including 7S RNA binding activity; endoplasmic reticulum signal peptide binding activity; and guanyl ribonucleotide binding activity. Contributes to GTPase activity. Involved in granulocyte differentiation and protein targeting to ER. Located in cytosol and nucleus. Part of signal recognition particle, endoplasmic reticulum targeting. Implicated in severe congenital neutropenia 8. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

504 residues, UniProt reviewed canonical sequence.

>P61011|SRP54
     1  MVLADLGRKI TSALRSLSNA TIINEEVLNA MLKEVCTALL EADVNIKLVK QLRENVKSAI
    61  DLEEMASGLN KRKMIQHAVF KELVKLVDPG VKAWTPTKGK QNVIMFVGLQ GSGKTTTCSK
   121  LAYYYQRKGW KTCLICADTF RAGAFDQLKQ NATKARIPFY GSYTEMDPVI IASEGVEKFK
   181  NENFEIIIVD TSGRHKQEDS LFEEMLQVAN AIQPDNIVYV MDASIGQACE AQAKAFKDKV
   241  DVASVIVTKL DGHAKGGGAL SAVAATKSPI IFIGTGEHID DFEPFKTQPF ISKLLGMGDI
   301  EGLIDKVNEL KLDDNEALIE KLKHGQFTLR DMYEQFQNIM KMGPFSQILG MIPGFGTDFM
   361  SKGNEQESMA RLKKLMTIMD SMNDQELDST DGAKVFSKQP GRIQRVARGS GVSTRDVQEL
   421  LTQYTKFAQM VKKMGGIKGL FKGGDMSKNV SQSQMAKLNQ QMAKMMDPRV LHHMGGMAGL
   481  QSMMRQFQQG AAGNMKGMMG FNNM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SRP54 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.31

Highest tissue expression

58 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SRP54.

Disease | AllUniProt

Conditions SRP54 is implicated in, by any mechanism.

• Neutropenia, severe congenital 8, autosomal dominant (SCN8) MIM:618752

Disease | GeneticClinVar

7 pathogenic / likely-pathogenic of 352 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Neutropenia, severe congenital, 8, autosomal dominant
• Shwachman-Diamond syndrome 1
• Inborn genetic diseases
• Ciliary dyskinesia, primary, 40

Disease | AutoantibodyPubMed

Conditions in which antibodies against SRP54 are reported. Each links to that disease's full target list.

• Myositis 68
• Dermatomyositis 14
• Polymyositis 14
• Lung Diseases, Interstitial 9
• Muscle Weakness 9
• Arthritis 3
• Scleroderma, Systemic 3

Showing 7 of 10 — disease pages carrying at least 10 antigens.

ReferencesPubMed · IEDB

Publications for SRP54 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.22

gnomAD pLI

1

gnomAD missense Z

3.45

DepMap mean gene effect

-2.26

DepMap dependency class

pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• exocrine pancreas development
• granulocyte differentiation
• neutrophil chemotaxis
• protein targeting to ER
• SRP-dependent cotranslational protein targeting to membrane
• SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition
• SRP-dependent cotranslational protein targeting to membrane, translocation

Molecular functions

• 7S RNA binding
• endoplasmic reticulum signal peptide binding
• GDP binding
• GTP binding
• GTPase activity
• ribonucleoprotein complex binding
• RNA binding

Cellular components

• cytoplasm
• cytosol
• endoplasmic reticulum
• nuclear speck
• nucleus
• signal recognition particle, endoplasmic reticulum targeting

Protein domainsUniProt · Pfam · InterPro

• Signal recognition particle, SRP54 subunit, GTPase domain
• AAA+ ATPase domain
• Signal recognition particle SRP54, helical bundle
• P-loop containing nucleoside triphosphate hydrolase
• SRP/SRP receptor, N-terminal
• Signal recognition particle SRP54, N-terminal domain superfamily
• SRP54-type protein, GTPase domain
• SRP54-type protein, helical bundle domain
• Signal recognition particle, SRP54 subunit, M-domain
• Signal recognition particle, SRP54 subunit, eukaryotic
• Signal recognition particle, SRP54 subunit
• Signal recognition particle, SRP54 subunit, M-domain superfamily
• Signal peptide binding domain

KeywordsUniProt

• Cytoplasm
• Endoplasmic reticulum
• GTP-binding
• Hydrolase
• Nucleotide-binding
• Nucleus
• Ribonucleoprotein
• RNA-binding
• Signal recognition particle

InteractionsUniProt · HPA

Protein binding partners of SRP54 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• RNPS1
• SRP14
• SRP19
• SRP68
• SRP72
• SRP9