Seroatlas · Human Serome Atlas

GSPT2

Eukaryotic peptide chain release factor GTP-binding subunit ERF3B

Also known as: eRF3b, ERF3B_HUMAN, FLJ10441

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IYD1
Gene: GSPT2
Ensembl: ENSG00000189369
Chromosome: X
Canonical length: 628 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

This gene encodes a GTPase that belongs to the GTP-binding elongation factor family. The encoded protein is a polypeptide release factor that complexes with eukaryotic peptide chain release factor 1 to mediate translation termination. This protein may also be involved in mRNA stability.[provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

628 residues, UniProt reviewed canonical sequence.

>Q8IYD1|GSPT2
     1  MDSGSSSSDS APDCWDQVDM ESPGSAPSGD GVSSAVAEAQ REPLSSAFSR KLNVNAKPFV
    61  PNVHAAEFVP SFLRGPTQPP TLPAGSGSND ETCTGAGYPQ GKRMGRGAPV EPSREEPLVS
   121  LEGSNSAVTM ELSEPVVENG EVEMALEESW EHSKEVSEAE PGGGSSGDSG PPEESGQEMM
   181  EEKEEIRKSK SVIVPSGAPK KEHVNVVFIG HVDAGKSTIG GQIMFLTGMV DKRTLEKYER
   241  EAKEKNRETW YLSWALDTNQ EERDKGKTVE VGRAYFETER KHFTILDAPG HKSFVPNMIG
   301  GASQADLAVL VISARKGEFE TGFEKGGQTR EHAMLAKTAG VKHLIVLINK MDDPTVNWSI
   361  ERYEECKEKL VPFLKKVGFS PKKDIHFMPC SGLTGANIKE QSDFCPWYTG LPFIPYLDNL
   421  PNFNRSIDGP IRLPIVDKYK DMGTVVLGKL ESGSIFKGQQ LVMMPNKHNV EVLGILSDDT
   481  ETDFVAPGEN LKIRLKGIEE EEILPGFILC DPSNLCHSGR TFDVQIVIIE HKSIICPGYN
   541  AVLHIHTCIE EVEITALISL VDKKSGEKSK TRPRFVKQDQ VCIARLRTAG TICLETFKDF
   601  PQMGRFTLRD EGKTIAIGKV LKLVPEKD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GSPT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

testis: 12 nTPM
hypothalamus: 11 nTPM
liver: 11 nTPM
thymus: 9.7 nTPM
cerebral cortex: 9.6 nTPM
basal ganglia: 9 nTPM

Single-cell type

late spermatids: 329 nCPM
early spermatids: 87 nCPM
late primary spermatocytes: 65 nCPM
müller glia: 53 nCPM
hepatocytes: 23 nCPM
other brain neurons: 19 nCPM

Immune cell

myeloid DC: 8.2 nTPM
naive B-cell: 8.1 nTPM
memory B-cell: 8 nTPM
plasmacytoid DC: 6.9 nTPM
NK-cell: 6.5 nTPM
naive CD4 T-cell: 6.3 nTPM

Brain region

hypothalamus: 22 nTPM
midbrain: 14 nTPM
basal ganglia: 14 nTPM
hippocampal formation: 13 nTPM
cerebral cortex: 13 nTPM
pons: 12 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GSPT2.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 42 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.24
gnomAD pLI: 0.98
gnomAD missense Z: 2.49
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GSPT2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GSPT2 as an antibody target. Whether an autoantibody or antibody against GSPT2 could matter depends on whether native GSPT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GSPT2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GSPT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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