Seroatlas · Human Serome Atlas

ZNG1E

Zinc-regulated GTPase metalloprotein activator 1E

Also known as: CBWD5, ZNG1E_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5RIA9
Gene: ZNG1E
Ensembl: ENSG00000147996
Chromosome: 9
Canonical length: 395 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

Predicted to enable GTPase activity and zinc chaperone activity. Predicted to be involved in protein maturation. Predicted to be located in nucleus. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

395 residues, UniProt reviewed canonical sequence.

>Q5RIA9|ZNG1E
     1  MLPAVGSVDE EEDPAEEDCP ELVPIETTQS EEEEKSGLGA KIPVTIITGY LGAGKTTLLN
    61  YILTEQHSKR VAVILNESGE GSALEKSLAV SQGGELYEEW LELRNGCLCC SVKDNGLRAI
   121  ENLMQKKGKF DDILLETTGL ADPGAVTSMF WVDAELGSDI YLDGIITIVD SKYGLKHLTE
   181  EKPDGLINEA TRQVALADII LINKTDLVPE EDVKKLRTTI RSINGLGQIL ETQRSRVDLS
   241  NVLDLHAFDS LSGISLQKKL QHVPGTQPHL DQSIVTITFE VPGNAKEEHL NMFIQNLLWE
   301  KNVRNKDNHC MEVIRLKGLV SIKDKSQQVI VQGVHELYDL EETPVSWKDD TERTNRLVLI
   361  GRNLDKDILK QLFIATVTET EKQWTTHFKE DQVCT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNG1E can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 42 nTPM

Expression across tissuesHPA

Tissue

liver: 42 nTPM
cerebellum: 33 nTPM
hippocampal formation: 25 nTPM
kidney: 24 nTPM
hypothalamus: 23 nTPM
basal ganglia: 23 nTPM

Single-cell type

enterocytes: 126 nCPM
breast hormone-responsive cells: 93 nCPM
brain inhibitory neurons: 79 nCPM
suprabasal keratinocytes: 76 nCPM
brain excitatory neurons: 75 nCPM
paneth cells: 74 nCPM

Immune cell

intermediate monocyte: 15 nTPM
myeloid DC: 13 nTPM
classical monocyte: 12 nTPM
total PBMC: 11 nTPM
non-classical monocyte: 10 nTPM
eosinophil: 8.9 nTPM

Brain region

hypothalamus: 6.9 nTPM
cerebellum: 5.7 nTPM
white matter: 5.7 nTPM
pons: 5 nTPM
medulla oblongata: 4.7 nTPM
midbrain: 4.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.95
gnomAD pLI: 0

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein maturation

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNG1E as an antibody target. Whether an autoantibody or antibody against ZNG1E could matter depends on whether native ZNG1E is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNG1E is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNG1E as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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