Seroatlas · Human Serome Atlas

RAB8B

Ras-related protein Rab-8B

Also known as: RAB8B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92930
Gene: RAB8B
Ensembl: ENSG00000166128
Chromosome: 15
Canonical length: 207 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

RAB proteins, like RAB8B, are low molecular mass monomeric GTPases that localize on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB proteins function in intracellular vesicle transport by aiding in the docking and/or fusion of vesicles with their target membranes (summary by Chen et al., 1997 [PubMed 9030196]).[supplied by OMIM, Nov 2010]

Canonical amino-acid sequenceUniProt

207 residues, UniProt reviewed canonical sequence.

>Q92930|RAB8B
     1  MAKTYDYLFK LLLIGDSGVG KTCLLFRFSE DAFNTTFIST IGIDFKIRTI ELDGKKIKLQ
    61  IWDTAGQERF RTITTAYYRG AMGIMLVYDI TNEKSFDNIK NWIRNIEEHA SSDVERMILG
   121  NKCDMNDKRQ VSKERGEKLA IDYGIKFLET SAKSSANVEE AFFTLARDIM TKLNRKMNDS
   181  NSAGAGGPVK ITENRSKKTS FFRCSLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB8B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 77 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 77 nTPM
lymph node: 40 nTPM
tonsil: 36 nTPM
thymus: 35 nTPM
spleen: 32 nTPM
ovary: 29 nTPM

Single-cell type

neutrophils: 1,696 nCPM
late spermatids: 617 nCPM
neutrophil progenitors: 574 nCPM
nk-cells: 568 nCPM
innate lymphoid cells: 443 nCPM
cdc: 405 nCPM

Immune cell

basophil: 62 nTPM
neutrophil: 57 nTPM
T-reg: 36 nTPM
total PBMC: 30 nTPM
gdT-cell: 27 nTPM
classical monocyte: 26 nTPM

Brain region

white matter: 34 nTPM
choroid plexus: 33 nTPM
spinal cord: 30 nTPM
thalamus: 29 nTPM
hippocampal formation: 29 nTPM
cerebral cortex: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0
gnomAD missense Z: 1.98
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

antigen processing and presentation
endocytic recycling
exocytosis
positive regulation of cell projection organization
positive regulation of corticotropin secretion
protein import into peroxisome membrane
cell-substrate junction organization

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB8B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB8B as an antibody target. Whether an autoantibody or antibody against RAB8B could matter depends on whether native RAB8B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB8B is annotated at the cell surface, where native RAB8B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RAB8B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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