GNA14

Protein identityUniProt · HPA

UniProt accession

O95837

Gene

GNA14

Ensembl

ENSG00000156049

Chromosome

9

Canonical length

355 aa

Protein class

Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the guanine nucleotide-binding, or G protein family. G proteins are heterotrimers consisting of alpha, beta and gamma subunits. The encoded protein is a member of the alpha family of G proteins, more specifically the alpha q subfamily of G proteins. The encoded protein may play a role in pertussis-toxin resistant activation of phospholipase C-beta and its downstream effectors.[provided by RefSeq, Feb 2009]

Canonical amino-acid sequenceUniProt

355 residues, UniProt reviewed canonical sequence.

>O95837|GNA14
     1  MAGCCCLSAE EKESQRISAE IERQLRRDKK DARRELKLLL LGTGESGKST FIKQMRIIHG
    61  SGYSDEDRKG FTKLVYQNIF TAMQAMIRAM DTLRIQYVCE QNKENAQIIR EVEVDKVSML
   121  SREQVEAIKQ LWQDPGIQEC YDRRREYQLS DSAKYYLTDI DRIATPSFVP TQQDVLRVRV
   181  PTTGIIEYPF DLENIIFRMV DVGGQRSERR KWIHCFESVT SIIFLVALSE YDQVLAECDN
   241  ENRMEESKAL FKTIITYPWF LNSSVILFLN KKDLLEEKIM YSHLISYFPE YTGPKQDVRA
   301  ARDFILKLYQ DQNPDKEKVI YSHFTCATDT DNIRFVFAAV KDTILQLNLR EFNLV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GNA14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.27

Highest tissue expression

18 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GNA14.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 71 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Congenital tufted angioma
• Pyogenic granuloma
• Kaposiform hemangioendothelioma
• Capillary malformation

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.71

gnomAD pLI

0

gnomAD missense Z

-0.38

DepMap mean gene effect

-0.01

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• action potential
• adenylate cyclase-modulating G protein-coupled receptor signaling pathway
• cell chemotaxis
• phospholipase C-activating dopamine receptor signaling pathway
• phospholipase C-activating G protein-coupled receptor signaling pathway
• positive regulation of inflammatory response
• signal transduction

Molecular functions

• G protein activity
• G protein-coupled receptor binding
• G-protein beta/gamma-subunit complex binding
• GTP binding
• GTPase activity
• metal ion binding

Cellular components

• cytoplasm
• extracellular exosome
• heterotrimeric G-protein complex
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• G-protein alpha subunit, group Q
• Guanine nucleotide binding protein, alpha subunit
• G protein alpha subunit, helical insertion
• P-loop containing nucleoside triphosphate hydrolase
• G-protein alpha subunit

KeywordsUniProt

• ADP-ribosylation
• GTP-binding
• Magnesium
• Metal-binding
• Nucleotide-binding
• Transducer

InteractionsUniProt · HPA

Protein binding partners of GNA14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• F2RL1