Seroatlas · Human Serome Atlas

NAT10

RNA cytidine acetyltransferase

Also known as: FLJ10774, FLJ12179, hALP, KIAA1709, Kre33, NAT10_HUMAN, NET43

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H0A0
Gene
NAT10
Ensembl
ENSG00000135372
Chromosome
11
Canonical length
1025 aa
Protein class
Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoli,Midbody

OverviewNCBI Gene

The protein encoded by this gene is an RNA cytidine acetyltransferase involved in histone acetylation, tRNA acetylation, the biosynthesis of 18S rRNA, and the enhancement of nuclear architecture and chromatin organization. [provided by RefSeq, Oct 2016]

Canonical amino-acid sequenceUniProt

1025 residues, UniProt reviewed canonical sequence.

>Q9H0A0|NAT10
     1  MHRKKVDNRI RILIENGVAE RQRSLFVVVG DRGKDQVVIL HHMLSKATVK ARPSVLWCYK
    61  KELGFSSHRK KRMRQLQKKI KNGTLNIKQD DPFELFIAAT NIRYCYYNET HKILGNTFGM
   121  CVLQDFEALT PNLLARTVET VEGGGLVVIL LRTMNSLKQL YTVTMDVHSR YRTEAHQDVV
   181  GRFNERFILS LASCKKCLVI DDQLNILPIS SHVATMEALP PQTPDESLGP SDLELRELKE
   241  SLQDTQPVGV LVDCCKTLDQ AKAVLKFIEG ISEKTLRSTV ALTAARGRGK SAALGLAIAG
   301  AVAFGYSNIF VTSPSPDNLH TLFEFVFKGF DALQYQEHLD YEIIQSLNPE FNKAVIRVNV
   361  FREHRQTIQY IHPADAVKLG QAELVVIDEA AAIPLPLVKS LLGPYLVFMA STINGYEGTG
   421  RSLSLKLIQQ LRQQSAQSQV STTAENKTTT TARLASARTL YEVSLQESIR YAPGDAVEKW
   481  LNDLLCLDCL NITRIVSGCP LPEACELYYV NRDTLFCYHK ASEVFLQRLM ALYVASHYKN
   541  SPNDLQMLSD APAHHLFCLL PPVPPTQNAL PEVLAVIQVC LEGEISRQSI LNSLSRGKKA
   601  SGDLIPWTVS EQFQDPDFGG LSGGRVVRIA VHPDYQGMGY GSRALQLLQM YYEGRFPCLE
   661  EKVLETPQEI HTVSSEAVSL LEEVITPRKD LPPLLLKLNE RPAERLDYLG VSYGLTPRLL
   721  KFWKRAGFVP VYLRQTPNDL TGEHSCIMLK TLTDEDEADQ GGWLAAFWKD FRRRFLALLS
   781  YQFSTFSPSL ALNIIQNRNM GKPAQPALSR EELEALFLPY DLKRLEMYSR NMVDYHLIMD
   841  MIPAISRIYF LNQLGDLALS AAQSALLLGI GLQHKSVDQL EKEIELPSGQ LMGLFNRIIR
   901  KVVKLFNEVQ EKAIEEQMVA AKDVVMEPTM KTLSDDLDEA AKEFQEKHKK EVGKLKSMDL
   961  SEYIIRGDDE EWNEVLNKAG PNASIISLKS DKKRKLEAKQ EPKQSKKLKN RETKNKKDMK
  1021  LKRKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NAT10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
27 nTPM

Expression across tissuesHPA

Tissue

  • skin: 27 nTPM
  • tonsil: 26 nTPM
  • esophagus: 25 nTPM
  • pancreas: 24 nTPM
  • adrenal gland: 23 nTPM
  • skeletal muscle: 23 nTPM

Single-cell type

  • erythrocyte progenitors: 74 nCPM
  • megakaryocyte-erythroid progenitors: 55 nCPM
  • megakaryocyte progenitors: 46 nCPM
  • differentiating spermatogonia: 44 nCPM
  • retinal pigment epithelial cells: 43 nCPM
  • thyrotrophs: 41 nCPM

Immune cell

  • MAIT T-cell: 16 nTPM
  • myeloid DC: 16 nTPM
  • NK-cell: 15 nTPM
  • intermediate monocyte: 14 nTPM
  • memory CD8 T-cell: 13 nTPM
  • naive CD8 T-cell: 13 nTPM

Brain region

  • cerebral cortex: 36 nTPM
  • white matter: 35 nTPM
  • basal ganglia: 33 nTPM
  • hypothalamus: 33 nTPM
  • hippocampal formation: 32 nTPM
  • pons: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.91
gnomAD pLI
0
gnomAD missense Z
1.17
DepMap mean gene effect
-1.18
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NAT10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NAT10 as an antibody target. Whether an autoantibody or antibody against NAT10 could matter depends on whether native NAT10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NAT10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NAT10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NAT10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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