Seroatlas · Human Serome Atlas

ZNG1C

Zinc-regulated GTPase metalloprotein activator 1C

Also known as: bA561O23.1, CBWD3, ZNG1C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5JTY5
Gene: ZNG1C
Ensembl: ENSG00000196873
Chromosome: 9
Canonical length: 395 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

Predicted to enable GTP binding activity; hydrolase activity; and metal ion binding activity. Predicted to be located in nucleus. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

395 residues, UniProt reviewed canonical sequence.

>Q5JTY5|ZNG1C
     1  MLPAVGSVDE EEDPAEEDCP ELVPIETTQS EEEEKSGLGA KIPVTIITGY LGAGKTTLLN
    61  YILTEQHSKR VAVILNESGE GSALEKSLAV SQGGELYEEW LELRNGCLCC SVKDNGLRAI
   121  ENLMQKKGKF DDILLETTGL ADPGAVASMF WVDAELGSDI YLDGIITIVD SKYGLKHLTE
   181  EKPDGLINEA TRQVALADII LINKTDLVPE EDVKKLRTTI RSINGLGQIL ETQRSRVDLS
   241  NVLDLHAFDS LSGISLQKKL QHVPGTQPHL DQSIVTITFE VPGNAKEEHL NMFIQNLLWE
   301  KNVRNKDNHC MEVIRLKGLV SIKDKSQQVI VQGVHELYDL EETPVSWKDD TERTNRLVLI
   361  GRNLDKDILK QLFIATVTET EKQWTTHFKE DQVCT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNG1C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 33 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 33 nTPM
liver: 26 nTPM
pancreas: 26 nTPM
kidney: 20 nTPM
small intestine: 19 nTPM
appendix: 18 nTPM

Single-cell type

enterocytes: 31 nCPM
microglia: 23 nCPM
sertoli cells: 22 nCPM
paneth cells: 19 nCPM
papillary tip epithelial cells: 19 nCPM
renal collecting duct principal cells: 18 nCPM

Immune cell

classical monocyte: 90 nTPM
neutrophil: 88 nTPM
intermediate monocyte: 77 nTPM
eosinophil: 68 nTPM
myeloid DC: 66 nTPM
total PBMC: 63 nTPM

Brain region

white matter: 27 nTPM
cerebellum: 25 nTPM
cerebral cortex: 25 nTPM
hypothalamus: 24 nTPM
pons: 23 nTPM
hippocampal formation: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.89
gnomAD pLI: 0

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNG1C as an antibody target. Whether an autoantibody or antibody against ZNG1C could matter depends on whether native ZNG1C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNG1C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNG1C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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