Seroatlas · Human Serome Atlas

KIF15

Kinesin-like protein KIF15

Also known as: HKLP2, KIF15_HUMAN, KNSL7, NY-BR-62

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NS87
Gene: KIF15
Ensembl: ENSG00000163808
Chromosome: 3
Canonical length: 1388 aa
Protein class: Disease related genes, Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable ATP hydrolysis activity; microtubule binding activity; and plus-end-directed microtubule motor activity. Predicted to be involved in centrosome separation; microtubule-based movement; and mitotic spindle assembly. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1388 residues, UniProt reviewed canonical sequence.

>Q9NS87|KIF15
     1  MAPGCKTELR SVTNGQSNQP SNEGDAIKVF VRIRPPAERS GSADGEQNLC LSVLSSTSLR
    61  LHSNPEPKTF TFDHVADVDT TQESVFATVA KSIVESCMSG YNGTIFAYGQ TGSGKTFTMM
   121  GPSESDNFSH NLRGVIPRSF EYLFSLIDRE KEKAGAGKSF LCKCSFIEIY NEQIYDLLDS
   181  ASAGLYLREH IKKGVFVVGA VEQVVTSAAE AYQVLSGGWR NRRVASTSMN RESSRSHAVF
   241  TITIESMEKS NEIVNIRTSL LNLVDLAGSE RQKDTHAEGM RLKEAGNINR SLSCLGQVIT
   301  ALVDVGNGKQ RHVCYRDSKL TFLLRDSLGG NAKTAIIANV HPGSRCFGET LSTLNFAQRA
   361  KLIKNKAVVN EDTQGNVSQL QAEVKRLKEQ LAELASGQTP PESFLTRDKK KTNYMEYFQE
   421  AMLFFKKSEQ EKKSLIEKVT QLEDLTLKKE KFIQSNKMIV KFREDQIIRL EKLHKESRGG
   481  FLPEEQDRLL SELRNEIQTL REQIEHHPRV AKYAMENHSL REENRRLRLL EPVKRAQEMD
   541  AQTIAKLEKA FSEISGMEKS DKNQQGFSPK AQKEPCLFAN TEKLKAQLLQ IQTELNNSKQ
   601  EYEEFKELTR KRQLELESEL QSLQKANLNL ENLLEATKAC KRQEVSQLNK IHAETLKIIT
   661  TPTKAYQLHS RPVPKLSPEM GSFGSLYTQN SSILDNDILN EPVPPEMNEQ AFEAISEELR
   721  TVQEQMSALQ AKLDEEEHKN LKLQQHVDKL EHHSTQMQEL FSSERIDWTK QQEELLSQLN
   781  VLEKQLQETQ TKNDFLKSEV HDLRVVLHSA DKELSSVKLE YSSFKTNQEK EFNKLSERHM
   841  HVQLQLDNLR LENEKLLESK ACLQDSYDNL QEIMKFEIDQ LSRNLQNFKK ENETLKSDLN
   901  NLMELLEAEK ERNNKLSLQF EEDKENSSKE ILKVLEAVRQ EKQKETAKCE QQMAKVQKLE
   961  ESLLATEKVI SSLEKSRDSD KKVVADLMNQ IQELRTSVCE KTETIDTLKQ ELKDINCKYN
  1021  SALVDREESR VLIKKQEVDI LDLKETLRLR ILSEDIERDM LCEDLAHATE QLNMLTEASK
  1081  KHSGLLQSAQ EELTKKEALI QELQHKLNQK KEEVEQKKNE YNFKMRQLEH VMDSAAEDPQ
  1141  SPKTPPHFQT HLAKLLETQE QEIEDGRASK TSLEHLVTKL NEDREVKNAE ILRMKEQLRE
  1201  MENLRLESQQ LIEKNWLLQG QLDDIKRQKE NSDQNHPDNQ QLKNEQEESI KERLAKSKIV
  1261  EEMLKMKADL EEVQSALYNK EMECLRMTDE VERTQTLESK AFQEKEQLRS KLEEMYEERE
  1321  RTSQEMEMLR KQVECLAEEN GKLVGHQNLH QKIQYVVRLK KENVRLAEET EKLRAENVFL
  1381  KEKKRSES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIF15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 8.6 nTPM

Expression across tissuesHPA

Tissue

thymus: 8.6 nTPM
testis: 6.8 nTPM
bone marrow: 4.9 nTPM
lymph node: 2.1 nTPM
tonsil: 2.1 nTPM
rectum: 1.5 nTPM

Single-cell type

early spermatids: 142 nCPM
late spermatids: 82 nCPM
late primary spermatocytes: 80 nCPM
erythrocyte progenitors: 42 nCPM
megakaryocyte progenitors: 37 nCPM
monocyte progenitors: 36 nCPM

Immune cell

T-reg: 0.2 nTPM
memory B-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebellum: 0.5 nTPM
cerebral cortex: 0.5 nTPM
midbrain: 0.4 nTPM
spinal cord: 0.4 nTPM
white matter: 0.4 nTPM
amygdala: 0.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KIF15.

Disease | AllUniProt

Conditions KIF15 is implicated in, by any mechanism.

Braddock-Carey syndrome 2 (BRDCS2) MIM:619981

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 210 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Braddock-carey syndrome 2

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.79
gnomAD pLI: 0
gnomAD missense Z: 1.57
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Kinesin motor domain
P-loop containing nucleoside triphosphate hydrolase
Hyaluronan-mediated motility receptor, C-terminal
Kinesin motor domain superfamily
Kinesin motor domain
Hyaluronan mediated motility receptor C-terminal
Kinesin-like protein KIF15/KIN-12

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KIF15 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIF15 as an antibody target. Whether an autoantibody or antibody against KIF15 could matter depends on whether native KIF15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIF15 is annotated at the cell surface, where native KIF15 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KIF15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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