RRAS2

Protein identityUniProt · HPA

UniProt accession

P62070

Gene

RRAS2

Ensembl

ENSG00000133818

Chromosome

11

Canonical length

204 aa

Protein class

Disease related genes, Human disease related genes, Predicted intracellular proteins, RAS pathway related proteins

OverviewNCBI Gene

This gene encodes a member of the R-Ras subfamily of Ras-like small GTPases. The encoded protein associates with the plasma membrane and may function as a signal transducer. This protein may play an important role in activating signal transduction pathways that control cell proliferation. Mutations in this gene are associated with the growth of certain tumors. Pseudogenes of this gene are found on chromosomes 1 and 2. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

Canonical amino-acid sequenceUniProt

204 residues, UniProt reviewed canonical sequence.

>P62070|RRAS2
     1  MAAAGWRDGS GQEKYRLVVV GGGGVGKSAL TIQFIQSYFV TDYDPTIEDS YTKQCVIDDR
    61  AARLDILDTA GQEEFGAMRE QYMRTGEGFL LVFSVTDRGS FEEIYKFQRQ ILRVKDRDEF
   121  PMILIGNKAD LDHQRQVTQE EGQQLARQLK VTYMEASAKI RMNVDQAFHE LVRVIRKFQE
   181  QECPPSPEPT RKEKDKKGCH CVIF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RRAS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.31

Highest tissue expression

42 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RRAS2.

Disease | AllUniProt

Conditions RRAS2 is implicated in, by any mechanism.

• Ovarian cancer (OC) MIM:167000
• Noonan syndrome 12 (NS12) MIM:618624

Disease | GeneticClinVar

11 pathogenic / likely-pathogenic of 109 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Noonan syndrome
• Noonan syndrome 12
• Inborn genetic diseases
• Germinoma
• Ovarian neoplasm

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.26

gnomAD pLI

0.97

gnomAD missense Z

1.78

DepMap mean gene effect

-0.07

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• osteoblast differentiation
• Ras protein signal transduction
• Schwann cell migration
• positive regulation of Schwann cell migration

Molecular functions

• G protein activity
• GDP binding
• GTP binding
• GTPase activity

Cellular components

• endoplasmic reticulum
• extracellular exosome
• focal adhesion
• Golgi membrane
• membrane
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Small GTPase
• Small GTP-binding domain
• Small GTPase, Ras-type
• P-loop containing nucleoside triphosphate hydrolase
• Ras family

KeywordsUniProt

• Acetylation
• Cell membrane
• Golgi apparatus
• GTP-binding
• Hydrolase
• Lipoprotein
• Membrane
• Methylation
• Nucleotide-binding
• Palmitate
• Phosphoprotein
• Prenylation
• Proto-oncogene

InteractionsUniProt · HPA

Protein binding partners of RRAS2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• RASSF5
• RASIP1
• RIN1