RAB42
Ras-related protein Rab-42
Also known as: MGC45806, RAB42_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8N4Z0
- Gene
- RAB42
- Ensembl
- ENSG00000188060
- Chromosome
- 1
- Canonical length
- 218 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Endoplasmic reticulum
OverviewNCBI Gene
Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
218 residues, UniProt reviewed canonical sequence.
>Q8N4Z0|RAB42
1 MEAEGCRYQF RVALLGDAAV GKTSLLRSYV AGAPGAPEPE PEPEPTVGAE CYRRALQLRA
61 GPRVKLQLWD TAGHERFRCI TRSFYRNVVG VLLVFDVTNR KSFEHIQDWH QEVMATQGPD
121 KVIFLLVGHK SDLQSTRCVS AQEAEELAAS LGMAFVETSV KNNCNVDLAF DTLADAIQQA
181 LQQGDIKLEE GWGGVRLIHK TQIPRSPSRK QHSGPCQCLocalizationUniProt · AlphaFold · HPA
Whether an antibody against RAB42 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.31
- Highest tissue expression
- 23 nTPM
Expression across tissuesHPA
Tissue
- thymus: 23 nTPM
- lymph node: 6.2 nTPM
- placenta: 4.3 nTPM
- tonsil: 3.3 nTPM
- choroid plexus: 2.8 nTPM
- lung: 2.6 nTPM
Single-cell type
- hofbauer cells: 161 nCPM
- late spermatids: 14 nCPM
- macrophages: 12 nCPM
- early spermatids: 7.4 nCPM
- kupffer cells: 6.1 nCPM
- respiratory deuterosomal cells: 5.2 nCPM
Immune cell
- basophil: 0.2 nTPM
- classical monocyte: 0.1 nTPM
- neutrophil: 0.1 nTPM
- NK-cell: 0.1 nTPM
- non-classical monocyte: 0.1 nTPM
- eosinophil: 0 nTPM
Brain region
- white matter: 9.2 nTPM
- thalamus: 6.5 nTPM
- medulla oblongata: 5.5 nTPM
- pons: 4.9 nTPM
- choroid plexus: 4.8 nTPM
- cerebellum: 4.5 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.94
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.11
- DepMap mean gene effect
- -0.1
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RAB42 as an antibody target. Whether an autoantibody or antibody against RAB42 could matter depends on whether native RAB42 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RAB42 is annotated at the cell surface, where native RAB42 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label RAB42 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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