Seroatlas · Human Serome Atlas

GVINP1

Interferon-induced very large GTPase 1

Also known as: GVIN1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z2Y8
Gene: GVINP1
Canonical length: 2422 aa

OverviewNCBI Gene

No narrative summary is available for GVINP1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

2422 residues, UniProt reviewed canonical sequence.

>Q7Z2Y8|GVINP1
     1  MATGEHTPDD PLLRGKRRQD LQEMLREVGL DVEYWLPKLQ EHLGVTCAQA LQHLDKNNLK
    61  KLKSQTQHPW EKLLNLSHSK SLSALLQESQ VERAKRKQKQ AEQALQELRD LLTEGKQRQE
   121  EAVRTREAEL RQAMDIPEEY WPSPEEPLRE LMENLQRQLN LMKWTLCHRQ NLPDRDVVRW
   181  ASGGLALQGI YKASHQRGLT EKREELLSVP KEFLLLGPQQ GTQMKTKEFT SPQAEFMFTQ
   241  MVEKLGFRLT TSAKDGNWGF SLEAGLDHSK HPESKETQQS SSENSYFCST KFSYIPLASC
   301  HFPIDQLQLS KPAVQELKCI EELLSQTTNP DRFSLLRHRI INFFHRFGSH VNQGPLHLGG
   361  IYWWKAISEG YCTEQLAEVR QQSAEALDIF IRDSYSGFGV KVAAGVNVSD SHSKTATQTK
   421  TSQNLQTKVQ LSVAQTGGPP EADGLVQWKA GLIASNQTWC VIDRGLQLVP VWDIILSSHR
   481  SNFKDPLQVA NFLKDSYTAL TSITAQIQNG EELLSAGKEA RVFLEDVKSW EVSDPEEQLK
   541  KLINFMKMLS QKLKSYDTWI NICLTDSLQN FLVNTINFCK KSSIYKTKCI KSHLRSLLDP
   601  HIYRVTNFPQ AHFIMQWIFQ SDSEQEQVNI SQFSQLIEIL KETQNNLMEV KVKSESPETV
   661  EEAQRKSTYE VSLALSCFLN YLQKTEQTDT QLLLLSIAAA AGYHVINNTF QSLLGCDELS
   721  FLLDEMQTAQ NKYQELKNIC SYRAQAFLVL TGLTATVGDT AISSEEKTQR MSLMRHHMGQ
   781  SLSKEVAHVL TKPGADHDWE NLEKDLRLLI NGDYEEVTIS SLQMEEVSKQ SLFYGKKQPH
   841  EPHDNENNKW EMIKNGAFLD LLQHLGLEHY YPKKLSKANF HLIYKTSVYN TQPSSEQELP
   901  FYFLQKLLMM DYELRYLVFK DDRNTEHQVH PNASDQEDEA FDPYENFFED SDSPTKSSST
   961  EPSPHIHPVD IQMTIFHCAD NFARQYILAK LSTCQFALPL LVPNPCTSQI EFSLWSLRQI
  1021  TRSWQEARKS PKGKNYYKNQ QMCCVSTSIV SFVRVGNGLS ASKSQIMNCL LSKRKHDVFF
  1081  HRHCTGSRKD CLLMGGMVEI CWFCPGGEDE DRFDNCVTFT NLHGDAKEHE QQLSFLKEVS
  1141  TVIVVLMSAS DDNEGNRKIV RNLWQSSRPL ICLLDDKEAT MTNISGQRMR MGIKNRNEAE
  1201  LTEELTTTIR HLLELSDTAL SLEDCSQIAH QQGFLIDEDQ RDCKEAKEKA QALMAFLGKM
  1261  KLSQIKEKLL PLQGQLWHHW CKKDKELYHL REKGNQSIEQ HKSEIETDKQ IIRHEQLARA
  1321  LPLNDLMQSV LQFLQEHSEI HTKLYFLQWL SVFLDKLTAG HLEELHEKQK YWWSLVQTVK
  1381  QKAPNSHSLI CLQSEIEAIS TEISDCTLGI EQLIREVGQI YEALEEASSI KKIFFSLPQI
  1441  AADLMISGVP IELMDGDAAY VPLTWVAAVF DKVSEKLGDK RLFVLSILGL QSSGKSTVLN
  1501  ALFGLQFTVS AGKCTQGAYM QLLKVEETFT EELGFDFVLA VDTEGLRAPE HSNKSKDRDN
  1561  ELVTFVIGLA NLTLINIFGE NPSEMQDILQ IVVQAFLRMK QVKIFPSCLF VHQNVGEATA
  1621  TDQTMDGRRR LEQKLDEMAA IAAEQEQCLD VTCFSDVIRF DVNTHVYYFA HLWDGNPPMA
  1681  PPNPRYSHNV QQLKSRILMT ATQESRGNIM KISDVKSRVQ DLWRGLMNEN FIFSFRNTQE
  1741  VMAMNKLETM YNHWTWELRS HVLGLQNQLI NQIQNGKIQT LEASTFEVLV TEKYEVVKQE
  1801  LEKYFNEGPC SKILIQCKAN FENKLIVLKE KLISDSKRQA NELISFKNQS QERLNKKKTD
  1861  YEKELLEKSR KLALTVKGKE LSEEELHEKF NQLWKKWVCD VSTTLPQVTE PDIDLDSENI
  1921  LWEYFKNKTN VVGLLTNSAE KFQINYDKHI KVNKKYNHIP MTLTVFEKEF INMTTDYIVS
  1981  RFNKIINNMW KQQCGYNPNY FHEILKTIEE EVKSASTQKR YTFTNTFIID LCVCLFQRAR
  2041  ENFKEMHRAF KRANDPVNYL ESKKDDFFTS FKISCQGATS IKTFVDVLWY KLTPAVSTTI
  2101  WEDMTFKIAG DMRATCPAFN GNRTNLEKHI LFSLAEEENF DNYWEYLHNS KSFFRSYIKN
  2161  HIKRYCSDNG GEKMKTFFEK SLIDIKNTIL SAIHESTSVA KDKSSTASEW LDLFCDCLGC
  2221  NLIFPRRDLI SIEHQEIKHT EFLKEAMSAA LDLTMKKIEQ NYSSKPIEAM VSKIEKMLSE
  2281  HLCGCWKQCP SCGAICTNTI PTHEGDHSVP FHRPQAVNGE EWYETDDFVI DCCTSLVASD
  2341  CLLVLRDGRN FPFKNYRQAG GDYAMWSITP DTSIQLYWKW FVSHFRSNLE EKYQKKFAGK
  2401  GKIPNAWAKI TKQDVLEDLK KQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GVINP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

GTP binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

P-loop containing nucleoside triphosphate hydrolase
Alpha/beta knot methyltransferases
Very large inducible GTPASE (VLIG)-type guanine nucleotide-binding (G) domain
Up-regulator of cell proliferation-like domain
Up-regulator of cell proliferation-like domain
URGCP-like GTPase domain
Interferon-induced very large GTPase 1 domain
Interferon-induced very large GTPase 1 domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GVINP1 as an antibody target. Whether an autoantibody or antibody against GVINP1 could matter depends on whether native GVINP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GVINP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GVINP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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