Seroatlas · Human Serome Atlas

GIMAP7

GTPase IMAP family member 7

Also known as: GIMA7_HUMAN, IAN7, MGC27027

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NHV1
Gene: GIMAP7
Ensembl: ENSG00000179144
Chromosome: 7
Canonical length: 300 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus,Vesicles
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

300 residues, UniProt reviewed canonical sequence.

>Q8NHV1|GIMAP7
     1  MAESEDRSLR IVLVGKTGSG KSATANTILG EEIFDSRIAA QAVTKNCQKA SREWQGRDLL
    61  VVDTPGLFDT KESLDTTCKE ISRCIISSCP GPHAIVLVLL LGRYTEEEQK TVALIKAVFG
   121  KSAMKHMVIL FTRKEELEGQ SFHDFIADAD VGLKSIVKEC GNRCCAFSNS KKTSKAEKES
   181  QVQELVELIE KMVQCNEGAY FSDDIYKDTE ERLKQREEVL RKIYTDQLNE EIKLVEEDKH
   241  KSEEEKEKEI KLLKLKYDEK IKNIREEAER NIFKDVFNRI WKMLSEIWHR FLSKCKFYSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GIMAP7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 159 nTPM

Expression across tissuesHPA

Tissue

lymph node: 159 nTPM
spleen: 117 nTPM
tonsil: 93 nTPM
appendix: 70 nTPM
lung: 58 nTPM
tongue: 52 nTPM

Single-cell type

vascular endothelial cells: 268 nCPM
lymphatic endothelial cells: 235 nCPM
nk-cells: 200 nCPM
t-cells: 187 nCPM
kupffer cells: 137 nCPM
monocytes: 67 nCPM

Immune cell

total PBMC: 2,582 nTPM
naive CD4 T-cell: 2,276 nTPM
memory CD4 T-cell: 1,768 nTPM
naive CD8 T-cell: 1,602 nTPM
memory CD8 T-cell: 1,441 nTPM
gdT-cell: 1,187 nTPM

Brain region

pons: 15 nTPM
medulla oblongata: 14 nTPM
thalamus: 13 nTPM
midbrain: 12 nTPM
spinal cord: 11 nTPM
white matter: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.61
DepMap mean gene effect: 0.15
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

GTP metabolic process

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GIMAP7 as an antibody target. Whether an autoantibody or antibody against GIMAP7 could matter depends on whether native GIMAP7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GIMAP7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GIMAP7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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