RAB14
Ras-related protein Rab-14
Also known as: FBP, RAB-14, RAB14_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P61106
- Gene
- RAB14
- Ensembl
- ENSG00000119396
- Chromosome
- 9
- Canonical length
- 215 aa
- Protein class
- Plasma proteins, Predicted intracellular proteins
- Subcellular location
- Vesicles
OverviewNCBI Gene
RAB14 belongs to the large RAB family of low molecular mass GTPases that are involved in intracellular membrane trafficking. These proteins act as molecular switches that flip between an inactive GDP-bound state and an active GTP-bound state in which they recruit downstream effector proteins onto membranes (Junutula et al., 2004 [PubMed 15004230]).[supplied by OMIM, Mar 2009]
Canonical amino-acid sequenceUniProt
215 residues, UniProt reviewed canonical sequence.
>P61106|RAB14
1 MATAPYNYSY IFKYIIIGDM GVGKSCLLHQ FTEKKFMADC PHTIGVEFGT RIIEVSGQKI
61 KLQIWDTAGQ ERFRAVTRSY YRGAAGALMV YDITRRSTYN HLSSWLTDAR NLTNPNTVII
121 LIGNKADLEA QRDVTYEEAK QFAEENGLLF LEASAKTGEN VEDAFLEAAK KIYQNIQDGS
181 LDLNAAESGV QHKPSAPQGG RLTSEPQPQR EGCGCLocalizationUniProt · AlphaFold · HPA
Whether an antibody against RAB14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.3
- Highest tissue expression
- 88 nTPM
Expression across tissuesHPA
Tissue
- liver: 88 nTPM
- esophagus: 60 nTPM
- tonsil: 57 nTPM
- kidney: 57 nTPM
- lung: 55 nTPM
- parathyroid gland: 54 nTPM
Single-cell type
- esophageal apical cells: 332 nCPM
- megakaryocytes: 321 nCPM
- ocular epithelial cells: 240 nCPM
- alveolar cells type 1: 230 nCPM
- suprabasal keratinocytes: 226 nCPM
- esophageal suprabasal cells: 200 nCPM
Immune cell
- non-classical monocyte: 48 nTPM
- intermediate monocyte: 46 nTPM
- basophil: 39 nTPM
- eosinophil: 36 nTPM
- myeloid DC: 35 nTPM
- neutrophil: 34 nTPM
Brain region
- white matter: 86 nTPM
- pons: 74 nTPM
- cerebellum: 73 nTPM
- hypothalamus: 73 nTPM
- spinal cord: 72 nTPM
- cerebral cortex: 69 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.21
- gnomAD pLI
- 0.99
- gnomAD missense Z
- 2.85
- DepMap mean gene effect
- -0.12
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- defense response to bacterium
- early endosome to Golgi transport
- endocytic recycling
- endosomal vesicle fusion
- fibroblast growth factor receptor signaling pathway
- Golgi to endosome transport
- intracellular protein transport
- intracellular transport
- phagolysosome assembly
- phagosome maturation
- regulation of embryonic development
- regulation of protein localization
- vesicle-mediated transport
Molecular functions
Cellular components
- cytosol
- early endosome
- early endosome membrane
- endomembrane system
- extracellular exosome
- Golgi membrane
- Golgi stack
- late endosome
- lysosomal membrane
- lysosome
- nuclear outer membrane-endoplasmic reticulum membrane network
- perinuclear region of cytoplasm
- phagocytic vesicle
- plasma membrane
- recycling endosome
- recycling endosome membrane
- rough endoplasmic reticulum
- tertiary granule membrane
- trans-Golgi network
- trans-Golgi network transport vesicle
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of RAB14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RAB14 as an antibody target. Whether an autoantibody or antibody against RAB14 could matter depends on whether native RAB14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RAB14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label RAB14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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