Seroatlas · Human Serome Atlas

LSG1

Large subunit GTPase 1 homolog

Also known as: FLJ11301, LSG1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H089
Gene
LSG1
Ensembl
ENSG00000041802
Chromosome
3
Canonical length
658 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear bodies,Cytosol

OverviewNCBI Gene

This gene encodes a protein related to the yeast large subunit GTPase 1. The encoded protein is necessary for cell viability and may localize in the endoplasmic reticulum, nucleus and cytoplasm.[provided by RefSeq, Feb 2009]

Canonical amino-acid sequenceUniProt

658 residues, UniProt reviewed canonical sequence.

>Q9H089|LSG1
     1  MGRRRAPAGG SLGRALMRHQ TQRSRSHRHT DSWLHTSELN DGYDWGRLNL QSVTEQSSLD
    61  DFLATAELAG TEFVAEKLNI KFVPAEARTG LLSFEESQRI KKLHEENKQF LCIPRRPNWN
   121  QNTTPEELKQ AEKDNFLEWR RQLVRLEEEQ KLILTPFERN LDFWRQLWRV IERSDIVVQI
   181  VDARNPLLFR CEDLECYVKE MDANKENVIL INKADLLTAE QRSAWAMYFE KEDVKVIFWS
   241  ALAGAIPLNG DSEEEANRDD RQSNTTKFGH SSFDQAEISH SESEHLPARD SPSLSENPTT
   301  DEDDSEYEDC PEEEEDDWQT CSEEDGPKEE DCSQDWKESS TADSEARSRK TPQKRQIHNF
   361  SHLVSKQELL ELFKELHTGR KVKDGQLTVG LVGYPNVGKS STINTIMGNK KVSVSATPGH
   421  TKHFQTLYVE PGLCLCDCPG LVMPSFVSTK AEMTCSGILP IDQMRDHVPP VSLVCQNIPR
   481  HVLEATYGIN IITPREDEDP HRPPTSEELL TAYGYMRGFM TAHGQPDQPR SARYILKDYV
   541  SGKLLYCHPP PGRDPVTFQH QHQRLLENKM NSDEIKMQLG RNKKAKQIEN IVDKTFFHQE
   601  NVRALTKGVQ AVMGYKPGSG VVTASTASSE NGAGKPWKKH GNRNKKEKSR RLYKHLDM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LSG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
27 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 27 nTPM
  • skeletal muscle: 24 nTPM
  • liver: 23 nTPM
  • skin: 20 nTPM
  • tonsil: 20 nTPM
  • epididymis: 19 nTPM

Single-cell type

  • mast cells: 74 nCPM
  • differentiating spermatogonia: 50 nCPM
  • vascular endothelial cells: 47 nCPM
  • erythrocyte progenitors: 43 nCPM
  • sertoli cells: 41 nCPM
  • syncytiotrophoblasts: 41 nCPM

Immune cell

  • NK-cell: 21 nTPM
  • myeloid DC: 17 nTPM
  • MAIT T-cell: 17 nTPM
  • memory B-cell: 17 nTPM
  • gdT-cell: 15 nTPM
  • T-reg: 15 nTPM

Brain region

  • midbrain: 22 nTPM
  • pons: 21 nTPM
  • white matter: 19 nTPM
  • medulla oblongata: 18 nTPM
  • hypothalamus: 18 nTPM
  • thalamus: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.89
gnomAD pLI
0
gnomAD missense Z
0.33
DepMap mean gene effect
-1.02
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 17% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LSG1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LSG1 as an antibody target. Whether an autoantibody or antibody against LSG1 could matter depends on whether native LSG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LSG1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LSG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LSG1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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