Seroatlas · Human Serome Atlas

RAB3D

Ras-related protein Rab-3D

Also known as: D2-2, GOV, RAB16, RAB3D_HUMAN, RAD3D

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95716
Gene: RAB3D
Ensembl: ENSG00000105514
Chromosome: 19
Canonical length: 219 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Enables myosin V binding activity. Involved in bone resorption and positive regulation of regulated secretory pathway. Located in cytoplasmic microtubule and secretory vesicle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

219 residues, UniProt reviewed canonical sequence.

>O95716|RAB3D
     1  MASAGDTQAG PRDAADQNFD YMFKLLLIGN SSVGKTSFLF RYADDSFTPA FVSTVGIDFK
    61  VKTVYRHDKR IKLQIWDTAG QERYRTITTA YYRGAMGFLL MYDIANQESF AAVQDWATQI
   121  KTYSWDNAQV ILVGNKCDLE DERVVPAEDG RRLADDLGFE FFEASAKENI NVKQVFERLV
   181  DVICEKMNES LEPSSSSGSN GKGPAVGDAP APQPSSCSC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB3D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 65 nTPM

Expression across tissuesHPA

Tissue

pancreas: 65 nTPM
skin: 50 nTPM
esophagus: 32 nTPM
salivary gland: 28 nTPM
stomach: 18 nTPM
bone marrow: 17 nTPM

Single-cell type

neutrophils: 77 nCPM
neutrophil progenitors: 48 nCPM
pancreatic acinar cells: 27 nCPM
papillary tip epithelial cells: 24 nCPM
monocyte progenitors: 22 nCPM
renal collecting duct principal cells: 19 nCPM

Immune cell

neutrophil: 169 nTPM
basophil: 124 nTPM
eosinophil: 96 nTPM
classical monocyte: 84 nTPM
intermediate monocyte: 51 nTPM
non-classical monocyte: 41 nTPM

Brain region

pons: 50 nTPM
medulla oblongata: 43 nTPM
hippocampal formation: 33 nTPM
hypothalamus: 31 nTPM
white matter: 29 nTPM
cerebral cortex: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.54
gnomAD pLI: 0
gnomAD missense Z: 0.89
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB3D in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB3D as an antibody target. Whether an autoantibody or antibody against RAB3D could matter depends on whether native RAB3D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB3D is annotated at the cell surface, where native RAB3D is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RAB3D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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