Seroatlas · Human Serome Atlas

KIF2C

Kinesin-like protein KIF2C

Also known as: CT139, KIF2C_HUMAN, KNSL6, MCAK

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99661
Gene: KIF2C
Ensembl: ENSG00000142945
Chromosome: 1
Canonical length: 725 aa
Protein class: Cancer-related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Midbody,Centrosome,Cytosol

OverviewNCBI Gene

This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

725 residues, UniProt reviewed canonical sequence.

>Q99661|KIF2C
     1  MAMDSSLQAR LFPGLAIKIQ RSNGLIHSAN VRTVNLEKSC VSVEWAEGGA TKGKEIDFDD
    61  VAAINPELLQ LLPLHPKDNL PLQENVTIQK QKRRSVNSKI PAPKESLRSR STRMSTVSEL
   121  RITAQENDME VELPAAANSR KQFSVPPAPT RPSCPAVAEI PLRMVSEEME EQVHSIRGSS
   181  SANPVNSVRR KSCLVKEVEK MKNKREEKKA QNSEMRMKRA QEYDSSFPNW EFARMIKEFR
   241  ATLECHPLTM TDPIEEHRIC VCVRKRPLNK QELAKKEIDV ISIPSKCLLL VHEPKLKVDL
   301  TKYLENQAFC FDFAFDETAS NEVVYRFTAR PLVQTIFEGG KATCFAYGQT GSGKTHTMGG
   361  DLSGKAQNAS KGIYAMASRD VFLLKNQPCY RKLGLEVYVT FFEIYNGKLF DLLNKKAKLR
   421  VLEDGKQQVQ VVGLQEHLVN SADDVIKMID MGSACRTSGQ TFANSNSSRS HACFQIILRA
   481  KGRMHGKFSL VDLAGNERGA DTSSADRQTR MEGAEINKSL LALKECIRAL GQNKAHTPFR
   541  ESKLTQVLRD SFIGENSRTC MIATISPGIS SCEYTLNTLR YADRVKELSP HSGPSGEQLI
   601  QMETEEMEAC SNGALIPGNL SKEEEELSSQ MSSFNEAMTQ IRELEEKAME ELKEIIQQGP
   661  DWLELSEMTE QPDYDLETFV NKAESALAQQ AKHFSALRDV IKALRLAMQL EEQASRQISS
   721  KKRPQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIF2C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 73 nTPM

Expression across tissuesHPA

Tissue

testis: 73 nTPM
thymus: 35 nTPM
bone marrow: 31 nTPM
tonsil: 18 nTPM
lymph node: 15 nTPM
rectum: 7.1 nTPM

Single-cell type

late spermatids: 3,085 nCPM
early spermatids: 552 nCPM
late primary spermatocytes: 164 nCPM
oocytes: 138 nCPM
monocyte progenitors: 78 nCPM
differentiating spermatogonia: 60 nCPM

Immune cell

T-reg: 2.9 nTPM
NK-cell: 2 nTPM
memory CD4 T-cell: 1.7 nTPM
memory CD8 T-cell: 1.2 nTPM
gdT-cell: 0.9 nTPM
plasmacytoid DC: 0.8 nTPM

Brain region

cerebellum: 5.3 nTPM
pons: 3.3 nTPM
choroid plexus: 2.7 nTPM
hypothalamus: 2.5 nTPM
medulla oblongata: 2.3 nTPM
spinal cord: 2.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KIF2C.

Disease | ImmuneIEDB

Conditions an epitope on KIF2C was assayed in.

melanoma T cell
skin melanoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.55
gnomAD pLI: 0
gnomAD missense Z: 1.39
DepMap mean gene effect: -0.31
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KIF2C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIF2C as an antibody target. Whether an autoantibody or antibody against KIF2C could matter depends on whether native KIF2C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIF2C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KIF2C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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