Seroatlas · Human Serome Atlas

RAB6B

Ras-related protein Rab-6B

Also known as: RAB6B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NRW1
Gene: RAB6B
Ensembl: ENSG00000154917
Chromosome: 3
Canonical length: 208 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Golgi apparatus,Basal body

OverviewNCBI Gene

Enables myosin V binding activity. Involved in Golgi organization and protein localization to Golgi membrane. Located in Golgi membrane; ciliary basal body; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

208 residues, UniProt reviewed canonical sequence.

>Q9NRW1|RAB6B
     1  MSAGGDFGNP LRKFKLVFLG EQSVGKTSLI TRFMYDSFDN TYQATIGIDF LSKTMYLEDR
    61  TVRLQLWDTA GQERFRSLIP SYIRDSTVAV VVYDITNLNS FQQTSKWIDD VRTERGSDVI
   121  IMLVGNKTDL ADKRQITIEE GEQRAKELSV MFIETSAKTG YNVKQLFRRV ASALPGMENV
   181  QEKSKEGMID IKLDKPQEPP ASEGGCSC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB6B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 131 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 131 nTPM
hippocampal formation: 70 nTPM
amygdala: 70 nTPM
hypothalamus: 68 nTPM
midbrain: 56 nTPM
basal ganglia: 53 nTPM

Single-cell type

megakaryocytes: 161 nCPM
platelets: 138 nCPM
other brain neurons: 74 nCPM
oocytes: 74 nCPM
brain inhibitory neurons: 64 nCPM
brain excitatory neurons: 64 nCPM

Immune cell

MAIT T-cell: 7.4 nTPM
memory CD8 T-cell: 1.7 nTPM
total PBMC: 0.8 nTPM
gdT-cell: 0.6 nTPM
naive CD8 T-cell: 0.4 nTPM
memory B-cell: 0.1 nTPM

Brain region

cerebral cortex: 467 nTPM
pons: 341 nTPM
white matter: 309 nTPM
basal ganglia: 308 nTPM
hippocampal formation: 285 nTPM
midbrain: 282 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.33
gnomAD pLI: 0.96
gnomAD missense Z: 2.49
DepMap mean gene effect: -0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB6B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB6B as an antibody target. Whether an autoantibody or antibody against RAB6B could matter depends on whether native RAB6B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB6B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RAB6B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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