Seroatlas · Human Serome Atlas

RABL6

Rab-like protein 6

Also known as: bA216L13.9, C9orf86, FLJ10101, FLJ13045, Parf, pp8875, RABL6_HUMAN, RBEL1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q3YEC7
Gene: RABL6
Ensembl: ENSG00000196642
Chromosome: 9
Canonical length: 729 aa
Protein class: Predicted intracellular proteins
Subcellular location: Centriolar satellite,Centrosome,Basal body,Cytosol

OverviewNCBI Gene

This gene encodes a member of the Ras superfamily of small GTPases. The encoded protein binds to both GTP and GDP and may play a role in cell growth and survival. Overexpression of this gene may play a role in breast cancer tumorigenesis, and pseudogenes of this gene are located on the long arm of chromosome 2 and the short arm of chromosome 18. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Canonical amino-acid sequenceUniProt

729 residues, UniProt reviewed canonical sequence.

>Q3YEC7|RABL6
     1  MFSALKKLVG SDQAPGRDKN IPAGLQSMNQ ALQRRFAKGV QYNMKIVIRG DRNTGKTALW
    61  HRLQGRPFVE EYIPTQEIQV TSIHWSYKTT DDIVKVEVWD VVDKGKCKKR GDGLKMENDP
   121  QEAESEMALD AEFLDVYKNC NGVVMMFDIT KQWTFNYILR ELPKVPTHVP VCVLGNYRDM
   181  GEHRVILPDD VRDFIDNLDR PPGSSYFRYA ESSMKNSFGL KYLHKFFNIP FLQLQRETLL
   241  RQLETNQLDM DATLEELSVQ QETEDQNYGI FLEMMEARSR GHASPLAANG QSPSPGSQSP
   301  VVPAGAVSTG SSSPGTPQPA PQLPLNAAPP SSVPPVPPSE ALPPPACPSA PAPRRSIISR
   361  LFGTSPATEA APPPPEPVPA AEGPATVQSV EDFVPDDRLD RSFLEDTTPA RDEKKVGAKA
   421  AQQDSDSDGE ALGGNPMVAG FQDDVDLEDQ PRGSPPLPAG PVPSQDITLS SEEEAEVAAP
   481  TKGPAPAPQQ CSEPETKWSS IPASKPRRGT APTRTAAPPW PGGVSVRTGP EKRSSTRPPA
   541  EMEPGKGEQA SSSESDPEGP IAAQMLSFVM DDPDFESEGS DTQRRADDFP VRDDPSDVTD
   601  EDEGPAEPPP PPKLPLPAFR LKNDSDLFGL GLEEAGPKES SEEGKEGKTP SKEKKKKKKK
   661  GKEEEEKAAK KKSKHKKSKD KEEGKEERRR RQQRPPRSRE RTAADELEAF LGGGAPGGRH
   721  PGGGDYEEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RABL6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 145 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 145 nTPM
cerebellum: 124 nTPM
basal ganglia: 112 nTPM
cerebral cortex: 99 nTPM
pancreas: 98 nTPM
amygdala: 90 nTPM

Single-cell type

colonocytes: 154 nCPM
erythrocyte progenitors: 106 nCPM
enteric transient amplifying cells: 95 nCPM
monocyte progenitors: 94 nCPM
esophageal apical cells: 92 nCPM
enterocytes: 90 nCPM

Immune cell

intermediate monocyte: 2.4 nTPM
NK-cell: 2.4 nTPM
T-reg: 2.3 nTPM
memory B-cell: 2.2 nTPM
naive B-cell: 2 nTPM
classical monocyte: 1.8 nTPM

Brain region

basal ganglia: 152 nTPM
cerebral cortex: 136 nTPM
amygdala: 117 nTPM
medulla oblongata: 113 nTPM
hippocampal formation: 111 nTPM
thalamus: 110 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.25
gnomAD pLI: 1
gnomAD missense Z: -0.12
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

P-loop containing nucleoside triphosphate hydrolase
Ras of Complex, Roc, domain of DAPkinase
Rab-like protein 6

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RABL6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RABL6 as an antibody target. Whether an autoantibody or antibody against RABL6 could matter depends on whether native RABL6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RABL6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RABL6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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