RAB22A
Ras-related protein Rab-22A
Also known as: RB22A_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9UL26
- Gene
- RAB22A
- Ensembl
- ENSG00000124209
- Chromosome
- 20
- Canonical length
- 194 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Golgi apparatus,Vesicles
OverviewNCBI Gene
The protein encoded by this gene is a member of the RAB family of small GTPases. The GTP-bound form of the encoded protein has been shown to interact with early-endosomal antigen 1, and may be involved in the trafficking of and interaction between endosomal compartments. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
194 residues, UniProt reviewed canonical sequence.
>Q9UL26|RAB22A
1 MALRELKVCL LGDTGVGKSS IVWRFVEDSF DPNINPTIGA SFMTKTVQYQ NELHKFLIWD
61 TAGQERFRAL APMYYRGSAA AIIVYDITKE ETFSTLKNWV KELRQHGPPN IVVAIAGNKC
121 DLIDVREVME RDAKDYADSI HAIFVETSAK NAININELFI EISRRIPSTD ANLPSGGKGF
181 KLRRQPSEPK RSCCLocalizationUniProt · AlphaFold · HPA
Whether an antibody against RAB22A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.32
- Highest tissue expression
- 11 nTPM
Expression across tissuesHPA
Tissue
- esophagus: 11 nTPM
- parathyroid gland: 11 nTPM
- cerebral cortex: 10 nTPM
- adrenal gland: 9.7 nTPM
- amygdala: 9.7 nTPM
- spinal cord: 9.7 nTPM
Single-cell type
- esophageal apical cells: 311 nCPM
- esophageal suprabasal cells: 213 nCPM
- neutrophils: 139 nCPM
- urothelial cells: 125 nCPM
- suprabasal keratinocytes: 124 nCPM
- adrenal medulla cells: 117 nCPM
Immune cell
- gdT-cell: 2.2 nTPM
- NK-cell: 2.2 nTPM
- MAIT T-cell: 2.1 nTPM
- non-classical monocyte: 2.1 nTPM
- neutrophil: 2 nTPM
- memory CD8 T-cell: 1.9 nTPM
Brain region
- cerebral cortex: 31 nTPM
- basal ganglia: 29 nTPM
- hypothalamus: 28 nTPM
- pons: 28 nTPM
- hippocampal formation: 28 nTPM
- medulla oblongata: 25 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.68
- gnomAD pLI
- 0.1
- gnomAD missense Z
- 1.69
- DepMap mean gene effect
- 0.05
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 16% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of RAB22A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RAB22A as an antibody target. Whether an autoantibody or antibody against RAB22A could matter depends on whether native RAB22A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RAB22A is annotated at the cell surface, where native RAB22A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label RAB22A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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