Seroatlas · Human Serome Atlas

NMRK1

Nicotinamide riboside kinase 1

Also known as: bA235O14.2, C9orf95, FLJ20559, NRK1, NRK1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NWW6
Gene: NMRK1
Ensembl: ENSG00000106733
Chromosome: 9
Canonical length: 199 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Centrosome,Cytosol

OverviewNCBI Gene

Nicotinamide adenine dinucleotide (NAD+) is essential for life in all organisms, both as a coenzyme for oxidoreductases and as a source of ADP-ribosyl groups used in various reactions. Nicotinic acid and nicotinamide, collectively known as niacin, are the vitamin precursors of NAD+. Nicotinamide riboside kinases, such as NRK1, function to synthesize NAD+ through nicotinamide mononucleotide using nicotinamide riboside as the precursor (Bieganowski and Brenner, 2004 [PubMed 15137942]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

199 residues, UniProt reviewed canonical sequence.

>Q9NWW6|NMRK1
     1  MKTFIIGISG VTNSGKTTLA KNLQKHLPNC SVISQDDFFK PESEIETDKN GFLQYDVLEA
    61  LNMEKMMSAI SCWMESARHS VVSTDQESAE EIPILIIEGF LLFNYKPLDT IWNRSYFLTI
   121  PYEECKRRRS TRVYQPPDSP GYFDGHVWPM YLKYRQEMQD ITWEVVYLDG TKSEEDLFLQ
   181  VYEDLIQELA KQKCLQVTA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NMRK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 60 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 60 nTPM
liver: 50 nTPM
pancreas: 35 nTPM
esophagus: 32 nTPM
kidney: 31 nTPM
cerebellum: 30 nTPM

Single-cell type

esophageal apical cells: 1,133 nCPM
esophageal suprabasal cells: 148 nCPM
extravillous trophoblasts: 121 nCPM
enterocytes: 119 nCPM
hofbauer cells: 118 nCPM
breast lactating cells: 111 nCPM

Immune cell

memory CD4 T-cell: 44 nTPM
naive CD4 T-cell: 40 nTPM
T-reg: 32 nTPM
MAIT T-cell: 31 nTPM
naive CD8 T-cell: 30 nTPM
memory CD8 T-cell: 29 nTPM

Brain region

cerebellum: 15 nTPM
cerebral cortex: 12 nTPM
choroid plexus: 11 nTPM
hypothalamus: 11 nTPM
pons: 11 nTPM
white matter: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.49
gnomAD pLI: 0
gnomAD missense Z: 0.33
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NMRK1 as an antibody target. Whether an autoantibody or antibody against NMRK1 could matter depends on whether native NMRK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NMRK1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NMRK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...