Seroatlas · Human Serome Atlas

RAP2C

Ras-related protein Rap-2c

Also known as: DKFZp313B211, RAP2C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y3L5
Gene: RAP2C
Ensembl: ENSG00000123728
Chromosome: X
Canonical length: 183 aa
Protein class: Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is a member of the Ras-related protein subfamily of the Ras GTPase superfamily. Members of this family are small GTPases that act as molecular switches to regulate cellular proliferation, differentiation, and apoptosis. This protein has been reported to activate in vitro transcriptional activity of the serum response element. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]

Canonical amino-acid sequenceUniProt

183 residues, UniProt reviewed canonical sequence.

>Q9Y3L5|RAP2C
     1  MREYKVVVLG SGGVGKSALT VQFVTGTFIE KYDPTIEDFY RKEIEVDSSP SVLEILDTAG
    61  TEQFASMRDL YIKNGQGFIL VYSLVNQQSF QDIKPMRDQI VRVKRYEKVP LILVGNKVDL
   121  EPEREVMSSE GRALAQEWGC PFMETSAKSK SMVDELFAEI VRQMNYSSLP EKQDQCCTTC
   181  VVQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAP2C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 86 nTPM

Expression across tissuesHPA

Tissue

endometrium: 86 nTPM
smooth muscle: 52 nTPM
bone marrow: 50 nTPM
liver: 44 nTPM
epididymis: 29 nTPM
lymph node: 25 nTPM

Single-cell type

neutrophils: 203 nCPM
cardiomyocytes: 180 nCPM
syncytiotrophoblasts: 86 nCPM
neutrophil progenitors: 74 nCPM
esophageal apical cells: 66 nCPM
monocytes: 61 nCPM

Immune cell

non-classical monocyte: 15 nTPM
eosinophil: 11 nTPM
intermediate monocyte: 8.9 nTPM
neutrophil: 8.1 nTPM
basophil: 6.8 nTPM
NK-cell: 6.8 nTPM

Brain region

medulla oblongata: 17 nTPM
hypothalamus: 16 nTPM
spinal cord: 16 nTPM
thalamus: 15 nTPM
white matter: 15 nTPM
midbrain: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.19
gnomAD pLI: 0.3
gnomAD missense Z: 1.73
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAP2C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAP2C as an antibody target. Whether an autoantibody or antibody against RAP2C could matter depends on whether native RAP2C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAP2C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RAP2C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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