KIF4A

Protein identityUniProt · HPA

UniProt accession

O95239

Gene

KIF4A

Ensembl

ENSG00000090889

Chromosome

X

Canonical length

1232 aa

Protein class

Disease related genes, Human disease related genes, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Midbody,Acrosome,Equatorial segment,Mid piece,Principal piece

OverviewNCBI Gene

This gene encodes a member of the kinesin 4 subfamily of kinesin related proteins. The encoded protein is an ATP dependent microtubule-based motor protein that is involved in the intracellular transport of membranous organelles. This protein also associates with condensed chromosome arms and may be involved in maintaining chromosome integrity during mitosis. This protein may also be involved in the organization of the central spindle prior to cytokinesis. A pseudogene of this gene is found on chromosome X.[provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

1232 residues, UniProt reviewed canonical sequence.

>O95239|KIF4A
     1  MKEEVKGIPV RVALRCRPLV PKEISEGCQM CLSFVPGEPQ VVVGTDKSFT YDFVFDPSTE
    61  QEEVFNTAVA PLIKGVFKGY NATVLAYGQT GSGKTYSMGG AYTAEQENEP TVGVIPRVIQ
   121  LLFKEIDKKS DFEFTLKVSY LEIYNEEILD LLCPSREKAQ INIREDPKEG IKIVGLTEKT
   181  VLVALDTVSC LEQGNNSRTV ASTAMNSQSS RSHAIFTISL EQRKKSDKNS SFRSKLHLVD
   241  LAGSERQKKT KAEGDRLKEG ININRGLLCL GNVISALGDD KKGGFVPYRD SKLTRLLQDS
   301  LGGNSHTLMI ACVSPADSNL EETLNTLRYA DRARKIKNKP IVNIDPQTAE LNHLKQQVQQ
   361  LQVLLLQAHG GTLPGSITVE PSENLQSLME KNQSLVEENE KLSRGLSEAA GQTAQMLERI
   421  ILTEQANEKM NAKLEELRQH AACKLDLQKL VETLEDQELK ENVEIICNLQ QLITQLSDET
   481  VACMAAAIDT AVEQEAQVET SPETSRSSDA FTTQHALRQA QMSKELVELN KALALKEALA
   541  RKMTQNDSQL QPIQYQYQDN IKELELEVIN LQKEKEELVL ELQTAKKDAN QAKLSERRRK
   601  RLQELEGQIA DLKKKLNEQS KLLKLKESTE RTVSKLNQEI RMMKNQRVQL MRQMKEDAEK
   661  FRQWKQKKDK EVIQLKERDR KRQYELLKLE RNFQKQSNVL RRKTEEAAAA NKRLKDALQK
   721  QREVADKRKE TQSRGMEGTA ARVKNWLGNE IEVMVSTEEA KRHLNDLLED RKILAQDVAQ
   781  LKEKKESGEN PPPKLRRRTF SLTEVRGQVS ESEDSITKQI ESLETEMEFR SAQIADLQQK
   841  LLDAESEDRP KQRWENIATI LEAKCALKYL IGELVSSKIQ VSKLESSLKQ SKTSCADMQK
   901  MLFEERNHFA EIETELQAEL VRMEQQHQEK VLYLLSQLQQ SQMAEKQLEE SVSEKEQQLL
   961  STLKCQDEEL EKMREVCEQN QQLLRENEII KQKLTLLQVA SRQKHLPKDT LLSPDSSFEY
  1021  VPPKPKPSRV KEKFLEQSMD IEDLKYCSEH SVNEHEDGDG DDDEGDDEEW KPTKLVKVSR
  1081  KNIQGCSCKG WCGNKQCGCR KQKSDCGVDC CCDPTKCRNR QQGKDSLGTV ERTQDSEGSF
  1141  KLEDPTEVTP GLSFFNPVCA TPNSKILKEM CDVEQVLSKK TPPAPSPFDL PELKHVATEY
  1201  QENKAPGKKK KRALASNTSF FSGCSPIEEE AH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIF4A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.44

Highest tissue expression

12 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KIF4A.

Disease | AllUniProt

Conditions KIF4A is implicated in, by any mechanism.

• Intellectual developmental disorder, X-linked 100 (XLID100) MIM:300923
• Taurodontism, microdontia, and dens invaginatus (TMDI) MIM:313490

Disease | GeneticClinVar

8 pathogenic / likely-pathogenic of 338 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Intellectual disability, X-linked 100
• Taurodontism, microdontia, and dens invaginatus
• Ventriculomegaly
• Multicystic kidney dysplasia
• Hydrocephalus

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.2

gnomAD pLI

1

gnomAD missense Z

2.56

DepMap mean gene effect

-0.63

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• anterograde axonal transport
• mitotic cytokinesis
• mitotic spindle midzone assembly
• mitotic spindle organization
• organelle organization
• spindle elongation

Molecular functions

• ATP binding
• DNA binding
• iron-sulfur cluster binding
• metal ion binding
• microtubule binding
• microtubule motor activity

Cellular components

• axon cytoplasm
• chromosome
• cytoplasm
• cytosol
• membrane
• microtubule associated complex
• midbody
• nuclear matrix
• spindle microtubule

Protein domainsUniProt · Pfam · InterPro

• Kinesin motor domain
• Kinesin motor domain, conserved site
• P-loop containing nucleoside triphosphate hydrolase
• Kinesin-like protein
• Kinesin motor domain superfamily
• Kinesin motor domain
• KIF21A-like domain

KeywordsUniProt

• ATP-binding
• Chromosome
• Coiled coil
• Cytoplasm
• Cytoskeleton
• DNA-binding
• Intellectual disability
• Iron
• Iron-sulfur
• Isopeptide bond
• Metal-binding
• Microtubule
• Motor protein
• Nucleotide-binding
• Nucleus
• Phosphoprotein
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of KIF4A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MMS19
• CIAO2B