FIGNL1

Protein identityUniProt · HPA

UniProt accession

Q6PIW4

Gene

FIGNL1

Ensembl

ENSG00000132436

Chromosome

7

Canonical length

674 aa

Protein class

Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the AAA ATPase family of proteins. The encoded protein is recruited to sites of DNA damage where it plays a role in DNA double-strand break repair via homologous recombination. This protein has also been shown to localize to the centrosome and inhibit ciliogenesis, and may regulate the proliferation and differentiation of osteoblasts. [provided by RefSeq, Oct 2016]

Canonical amino-acid sequenceUniProt

674 residues, UniProt reviewed canonical sequence.

>Q6PIW4|FIGNL1
     1  MQTSSSRSVH LSEWQKNYFA ITSGICTGPK ADAYRAQILR IQYAWANSEI SQVCATKLFK
    61  KYAEKYSAII DSDNVESGLN NYAENILTLA GSQQTDSDKW QSGLSINNVF KMSSVQKMMQ
   121  AGKKFKDSLL EPALASVVIH KEATVFDLPK FSVCGSSQES DSLPNSAHDR DRTQDFPESN
   181  RLKLLQNAQP PMVTNTARTC PTFSAPVGES ATAKFHVTPL FGNVKKENHS SAKENIGLNV
   241  FLSNQSCFPA ACENPQRKSF YGSGTIDALS NPILNKACSK TEDNGPKEDS SLPTFKTAKE
   301  QLWVDQQKKY HQPQRASGSS YGGVKKSLGA SRSRGILGKF VPPIPKQDGG EQNGGMQCKP
   361  YGAGPTEPAH PVDERLKNLE PKMIELIMNE IMDHGPPVNW EDIAGVEFAK ATIKEIVVWP
   421  MLRPDIFTGL RGPPKGILLF GPPGTGKTLI GKCIASQSGA TFFSISASSL TSKWVGEGEK
   481  MVRALFAVAR CQQPAVIFID EIDSLLSQRG DGEHESSRRI KTEFLVQLDG ATTSSEDRIL
   541  VVGATNRPQE IDEAARRRLV KRLYIPLPEA SARKQIVINL MSKEQCCLSE EEIEQIVQQS
   601  DAFSGADMTQ LCREASLGPI RSLQTADIAT ITPDQVRPIA YIDFENAFRT VRPSVSPKDL
   661  ELYENWNKTF GCGK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FIGNL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.47

Highest tissue expression

12 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.79

gnomAD pLI

0

gnomAD missense Z

-0.52

DepMap mean gene effect

0.07

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• ATP metabolic process
• cellular response to ionizing radiation
• male meiotic nuclear division
• microtubule severing
• negative regulation of apoptotic process
• negative regulation of intrinsic apoptotic signaling pathway
• osteoblast differentiation
• osteoblast proliferation
• regulation of cell cycle
• regulation of double-strand break repair via homologous recombination

Molecular functions

• ATP binding
• ATP hydrolysis activity
• hydrolase activity
• magnesium ion binding
• microtubule severing ATPase activity

Cellular components

• cytoplasm
• extracellular exosome
• nuclear chromosome
• nucleoplasm
• nucleus
• perinuclear region of cytoplasm

Protein domainsUniProt · Pfam · InterPro

• AAA+ ATPase domain
• ATPase, AAA-type, core
• ATPase, AAA-type, conserved site
• Spastin/Vps4, C-terminal
• P-loop containing nucleoside triphosphate hydrolase
• AAA ATPase, AAA+ lid domain
• Microtubule-severing AAA ATPase
• ATPase family associated with various cellular activities (AAA)
• Vps4 C terminal oligomerisation domain
• AAA+ lid domain
• Fidgetin-like 1, ATPase domain

KeywordsUniProt

• Acetylation
• ATP-binding
• Cytoplasm
• Hydrolase
• Isopeptide bond
• Magnesium
• Metal-binding
• Nucleotide-binding
• Nucleus
• Phosphoprotein
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of FIGNL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• FIRRM
• RAD51
• SPIDR