Seroatlas · Human Serome Atlas

HS3ST5

Heparan sulfate glucosamine 3-O-sulfotransferase 5

Also known as: 3-OST-5, HS3S5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IZT8
Gene: HS3ST5
Ensembl: ENSG00000249853
Chromosome: 6
Canonical length: 346 aa
Protein class: Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

HS3ST5 belongs to a group of heparan sulfate 3-O-sulfotransferases (EC 2.8.2.23) that transfer sulfate from 3-prime-phosphoadenosine 5-prime phosphosulfate (PAPS) to heparan sulfate and heparin (Mochizuki et al., 2003 [PubMed 12740361]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

346 residues, UniProt reviewed canonical sequence.

>Q8IZT8|HS3ST5
     1  MLFKQQAWLR QKLLVLGSLA VGSLLYLVAR VGSLDRLQPI CPIEGRLGGA RTQAEFPLRA
    61  LQFKRGLLHE FRKGNASKEQ VRLHDLVQQL PKAIIIGVRK GGTRALLEML NLHPAVVKAS
   121  QEIHFFDNDE NYGKGIEWYR KKMPFSYPQQ ITIEKSPAYF ITEEVPERIY KMNSSIKLLI
   181  IVREPTTRAI SDYTQVLEGK ERKNKTYYKF EKLAIDPNTC EVNTKYKAVR TSIYTKHLER
   241  WLKYFPIEQF HVVDGDRLIT EPLPELQLVE KFLNLPPRIS QYNLYFNATR GFYCLRFNII
   301  FNKCLAGSKG RIHPEVDPSV ITKLRKFFHP FNQKFYQITG RTLNWP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HS3ST5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 6.9 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 6.9 nTPM
spinal cord: 5.3 nTPM
cerebral cortex: 3 nTPM
skeletal muscle: 3 nTPM
midbrain: 2.7 nTPM
hippocampal formation: 2.1 nTPM

Single-cell type

oligodendrocytes: 676 nCPM
myosatellite cells: 390 nCPM
myonuclei: 351 nCPM
renal collecting duct principal cells: 342 nCPM
brain inhibitory neurons: 315 nCPM
cone photoreceptor cells: 308 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 23 nTPM
thalamus: 19 nTPM
pons: 18 nTPM
midbrain: 18 nTPM
medulla oblongata: 18 nTPM
spinal cord: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.74
gnomAD pLI: 0.17
gnomAD missense Z: 1.29
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HS3ST5 as an antibody target. Whether an autoantibody or antibody against HS3ST5 could matter depends on whether native HS3ST5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HS3ST5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HS3ST5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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