Seroatlas · Human Serome Atlas

RAB27B

Ras-related protein Rab-27B

Also known as: RB27B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O00194
Gene: RAB27B
Ensembl: ENSG00000041353
Chromosome: 18
Canonical length: 218 aa
Protein class: Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Golgi apparatus,Plasma membrane,Cytosol

OverviewNCBI Gene

Enables guanyl ribonucleotide binding activity; myosin V binding activity; and protein domain specific binding activity. Involved in multivesicular body sorting pathway and positive regulation of exocytosis. Located in Golgi stack and cytoplasmic vesicle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

218 residues, UniProt reviewed canonical sequence.

>O00194|RAB27B
     1  MTDGDYDYLI KLLALGDSGV GKTTFLYRYT DNKFNPKFIT TVGIDFREKR VVYNAQGPNG
    61  SSGKAFKVHL QLWDTAGQER FRSLTTAFFR DAMGFLLMFD LTSQQSFLNV RNWMSQLQAN
   121  AYCENPDIVL IGNKADLPDQ REVNERQARE LADKYGIPYF ETSAATGQNV EKAVETLLDL
   181  IMKRMEQCVE KTQIPDTVNG GNSGNLDGEK PPEKKCIC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB27B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 42 nTPM

Expression across tissuesHPA

Tissue

stomach: 42 nTPM
prostate: 19 nTPM
skin: 15 nTPM
cerebral cortex: 14 nTPM
salivary gland: 13 nTPM
esophagus: 13 nTPM

Single-cell type

platelets: 1,214 nCPM
megakaryocytes: 933 nCPM
mast cells: 618 nCPM
foveolar cells: 567 nCPM
megakaryocyte progenitors: 377 nCPM
esophageal apical cells: 306 nCPM

Immune cell

NK-cell: 2.6 nTPM
gdT-cell: 2.2 nTPM
total PBMC: 1.6 nTPM
memory CD8 T-cell: 1.1 nTPM
naive CD8 T-cell: 1 nTPM
memory CD4 T-cell: 0.7 nTPM

Brain region

cerebral cortex: 46 nTPM
basal ganglia: 38 nTPM
hypothalamus: 30 nTPM
white matter: 26 nTPM
thalamus: 22 nTPM
hippocampal formation: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.86
gnomAD pLI: 0.04
gnomAD missense Z: 0.18
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB27B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB27B as an antibody target. Whether an autoantibody or antibody against RAB27B could matter depends on whether native RAB27B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB27B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RAB27B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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