Seroatlas · Human Serome Atlas

SBNO2

Protein strawberry notch homolog 2

Also known as: FLJ00173, KIAA0963, SBNO2_HUMAN, Sno, Stno

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y2G9
Gene: SBNO2
Ensembl: ENSG00000064932
Chromosome: 19
Canonical length: 1366 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable chromatin DNA binding activity and histone binding activity. Involved in several processes, including cellular response to interleukin-6; macrophage activation involved in immune response; and negative regulation of DNA-templated transcription. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1366 residues, UniProt reviewed canonical sequence.

>Q9Y2G9|SBNO2
     1  MLAVGPAMDR DYPQHEPPPA GSLLYSPPPL QSAMLHCPYW NTFSLPPYPA FSSDSRPFMS
    61  SASFLGSQPC PDTSYAPVAT ASSLPPKTCD FAQDSSYFED FSNISIFSSS VDSLSDIVDT
   121  PDFLPADSLN QVSTIWDDNP APSTHDKLFQ LSRPFAGFED FLPSHSTPLL VSYQEQSVQS
   181  QPEEEDEAEE EEAEELGHTE TYADYVPSKS KIGKQHPDRV VETSTLSSVP PPDITYTLAL
   241  PSDSGALSAL QLEAITYACQ QHEVLLPSGQ RAGFLIGDGA GVGKGRTVAG VILENHLRGR
   301  KKALWFSVSN DLKYDAERDL RDIEATGIAV HALSKIKYGD TTTSEGVLFA TYSALIGESQ
   361  AGGQHRTRLR QILDWCGEAF EGVIVFDECH KAKNAGSTKM GKAVLDLQNK LPLARVVYAS
   421  ATGASEPRNM IYMSRLGIWG EGTPFRNFEE FLHAIEKRGV GAMEIVAMDM KVSGMYIARQ
   481  LSFSGVTFRI EEIPLAPAFE CVYNRAALLW AEALNVFQQA ADWIGLESRK SLWGQFWSAH
   541  QRFFKYLCIA AKVRRLVELA REELARDKCV VIGLQSTGEA RTREVLGEND GHLNCFVSAA
   601  EGVFLSLIQK HFPSTKRKRD RGAGSKRKRR PRGRGAKAPR LACETAGVIR ISDDSSTESD
   661  PGLDSDFNSS PESLVDDDVV IVDAVGLPSD DRGPLCLLQR DPHGPGVLER VERLKQDLLD
   721  KVRRLGRELP VNTLDELIDQ LGGPQRVAEM TGRKGRVVSR PDGTVAFESR AEQGLSIDHV
   781  NLREKQRFMS GEKLVAIISE ASSSGVSLQA DRRVQNQRRR VHMTLELPWS ADRAIQQFGR
   841  THRSNQVSAP EYVFLISELA GERRFASIVA KRLESLGALT HGDRRATESR DLSKYNFENK
   901  YGTRALHCVL TTILSQTENK VPVPQGYPGG VPTFFRDMKQ GLLSVGIGGR ESRNGCLDVE
   961  KDCSITKFLN RILGLEVHKQ NALFQYFSDT FDHLIEMDKR EGKYDMGILD LAPGIEEIYE
  1021  ESQQVFLAPG HPQDGQVVFY KISVDRGLKW EDAFAKSLAL TGPYDGFYLS YKVRGNKPSC
  1081  LLAEQNRGQF FTVYKPNIGR QSQLEALDSL RRKFHRVTAE EAKEPWESGY ALSLTHCSHS
  1141  AWNRHCRLAQ EGKDCLQGLR LRHHYMLCGA LLRVWGRIAA VMADVSSSSY LQIVRLKTKD
  1201  RKKQVGIKIP EGCVRRVLQE LRLMDADVKR RQAPALGCPA PPAPRPLALP CGPGEVLDLT
  1261  YSPPAEAFPP PPHFSFPAPL SLDAGPGVVP LGTPDAQADP AALAHQGCDI NFKEVLEDML
  1321  RSLHAGPPSE GALGEGAGAG GAAGGGPERQ SVIQFSPPFP GAQAPL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SBNO2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 65 nTPM

Expression across tissuesHPA

Tissue

lung: 65 nTPM
adipose tissue: 57 nTPM
spleen: 57 nTPM
esophagus: 49 nTPM
salivary gland: 42 nTPM
kidney: 41 nTPM

Single-cell type

epicardial cells: 127 nCPM
papillary tip epithelial cells: 52 nCPM
neutrophils: 40 nCPM
renal connecting tubule cells: 37 nCPM
distal convoluted tubule cells: 36 nCPM
loop of henle epithelial cells: 35 nCPM

Immune cell

neutrophil: 2.5 nTPM
classical monocyte: 0.3 nTPM
intermediate monocyte: 0.2 nTPM
memory CD8 T-cell: 0.2 nTPM
eosinophil: 0.1 nTPM
gdT-cell: 0.1 nTPM

Brain region

medulla oblongata: 39 nTPM
thalamus: 33 nTPM
pons: 25 nTPM
midbrain: 25 nTPM
cerebral cortex: 24 nTPM
white matter: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.41
gnomAD pLI: 0.01
gnomAD missense Z: 2.44
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SBNO2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TAL1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SBNO2 as an antibody target. Whether an autoantibody or antibody against SBNO2 could matter depends on whether native SBNO2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SBNO2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SBNO2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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