Seroatlas · Human Serome Atlas

ARFRP1

ADP-ribosylation factor-related protein 1

Also known as: ARFRP_HUMAN, ARL18, ARP, Arp1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13795
Gene: ARFRP1
Ensembl: ENSG00000101246
Chromosome: 20
Canonical length: 201 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus

OverviewNCBI Gene

The protein encoded by this gene is a membrane-associated GTP-ase which localizes to the plasma membrane and is related to the ADP-ribosylation factor (ARF) and ARF-like (ARL) proteins. This gene plays a role in membrane trafficking between the trans-Golgi network and endosomes. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, May 2012]

Canonical amino-acid sequenceUniProt

201 residues, UniProt reviewed canonical sequence.

>Q13795|ARFRP1
     1  MYTLLSGLYK YMFQKDEYCI LILGLDNAGK TTFLEQSKTR FNKNYKGMSL SKITTTVGLN
    61  IGTVDVGKAR LMFWDLGGQE ELQSLWDKYY AECHGVIYVI DSTDEERLAE SKQAFEKVVT
   121  SEALCGVPVL VLANKQDVET CLSIPDIKTA FSDCTSKIGR RDCLTQACSA LTGKGVREGI
   181  EWMVKCVVRN VHRPPRQRDI T

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARFRP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 41 nTPM

Expression across tissuesHPA

Tissue

spleen: 41 nTPM
heart muscle: 39 nTPM
liver: 36 nTPM
esophagus: 35 nTPM
kidney: 35 nTPM
basal ganglia: 32 nTPM

Single-cell type

esophageal suprabasal cells: 67 nCPM
esophageal apical cells: 63 nCPM
esophageal basal cells: 61 nCPM
early primary spermatocytes: 55 nCPM
cytotrophoblasts: 50 nCPM
decidual stromal cells: 49 nCPM

Immune cell

plasmacytoid DC: 49 nTPM
naive CD4 T-cell: 47 nTPM
basophil: 44 nTPM
gdT-cell: 42 nTPM
naive CD8 T-cell: 42 nTPM
memory CD8 T-cell: 40 nTPM

Brain region

thalamus: 19 nTPM
white matter: 17 nTPM
amygdala: 17 nTPM
midbrain: 17 nTPM
basal ganglia: 17 nTPM
cerebral cortex: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.64
gnomAD pLI: 0.14
gnomAD missense Z: 0.85
DepMap mean gene effect: -0.74
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARFRP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SYS1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARFRP1 as an antibody target. Whether an autoantibody or antibody against ARFRP1 could matter depends on whether native ARFRP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARFRP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARFRP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...