Seroatlas · Human Serome Atlas

ARL9

ADP-ribosylation factor-like protein 9

Also known as: ARL9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6T311
Gene: ARL9
Ensembl: ENSG00000196503
Chromosome: 4
Canonical length: 187 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Centriolar satellite,Cytosol

OverviewNCBI Gene

ARL9 is a member of the small GTPase protein family with a high degree of similarity to ARF (MIM 103180) proteins of the RAS superfamily.[supplied by OMIM, Nov 2008]

Canonical amino-acid sequenceUniProt

187 residues, UniProt reviewed canonical sequence.

>Q6T311|ARL9
     1  MRPTWKALSH PAWPEEKNKQ ILVLGLDGAG KTSVLHSLAS NRVQHSVAPT QGFHAVCINT
    61  EDSQMEFLEI GGSKPFRSYW EMYLSKGLLL IFVVDSADHS RLPEAKKYLH QLIAANPVLP
   121  LVVFANKQDL EAAYHITDIH EALALSEVGN DRKMFLFGTY LTKNGSEIPS TMQDAKDLIA
   181  QLAADVQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARL9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 11 nTPM
testis: 8.3 nTPM
bone marrow: 2.1 nTPM
basal ganglia: 1.8 nTPM
skin: 1.7 nTPM
cerebral cortex: 1.6 nTPM

Single-cell type

late spermatids: 443 nCPM
early spermatids: 113 nCPM
late primary spermatocytes: 98 nCPM
retinal pigment epithelial cells: 60 nCPM
pituicytes/fscs: 34 nCPM
gastric progenitor cells: 28 nCPM

Immune cell

plasmacytoid DC: 0.3 nTPM
memory CD4 T-cell: 0.2 nTPM
naive CD4 T-cell: 0.2 nTPM
T-reg: 0.2 nTPM
memory CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM

Brain region

choroid plexus: 10 nTPM
medulla oblongata: 5 nTPM
hypothalamus: 3.6 nTPM
cerebellum: 3.3 nTPM
midbrain: 3.3 nTPM
pons: 3.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.86
gnomAD pLI: 0.44
gnomAD missense Z: 0.07
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

nervous system development

Molecular functions

Protein domainsUniProt · Pfam · InterPro

Small GTP-binding domain
Small GTPase superfamily, ARF/SAR type
P-loop containing nucleoside triphosphate hydrolase
ADP-ribosylation factor family
Small GTPase Arf-like protein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARL9 as an antibody target. Whether an autoantibody or antibody against ARL9 could matter depends on whether native ARL9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARL9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARL9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...