HS3ST2
Heparan sulfate glucosamine 3-O-sulfotransferase 2
Also known as: 3OST2, HS3S2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9Y278
- Gene
- HS3ST2
- Ensembl
- ENSG00000122254
- Chromosome
- 16
- Canonical length
- 367 aa
- Protein class
- Enzymes, Metabolic proteins, Predicted intracellular proteins
OverviewNCBI Gene
Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity. This gene is expressed predominantly in brain and may play a role in the nervous system. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
367 residues, UniProt reviewed canonical sequence.
>Q9Y278|HS3ST2
1 MAYRVLGRAG PPQPRRARRL LFAFTLSLSC TYLCYSFLCC CDDLGRSRLL GAPRCLRGPS
61 AGGQKLLQKS RPCDPSGPTP SEPSAPSAPA AAVPAPRLSG SNHSGSPKLG TKRLPQALIV
121 GVKKGGTRAV LEFIRVHPDV RALGTEPHFF DRNYGRGLDW YRSLMPRTLE SQITLEKTPS
181 YFVTQEAPRR IFNMSRDTKL IVVVRNPVTR AISDYTQTLS KKPDIPTFEG LSFRNRTLGL
241 VDVSWNAIRI GMYVLHLESW LQYFPLAQIH FVSGERLITD PAGEMGRVQD FLGIKRFITD
301 KHFYFNKTKG FPCLKKTESS LLPRCLGKSK GRTHVQIDPE VIDQLREFYR PYNIKFYETV
361 GQDFRWELocalizationUniProt · AlphaFold · HPA
Whether an antibody against HS3ST2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.39
- Highest tissue expression
- 20 nTPM
Expression across tissuesHPA
Tissue
- cerebral cortex: 20 nTPM
- blood vessel: 7.2 nTPM
- hippocampal formation: 6 nTPM
- lung: 5 nTPM
- hypothalamus: 3.5 nTPM
- adipose tissue: 2.9 nTPM
Single-cell type
- macrophages: 252 nCPM
- lymphatic endothelial cells: 214 nCPM
- vascular smooth muscle cells: 156 nCPM
- retinal bipolar cells: 115 nCPM
- vascular endothelial cells: 99 nCPM
- hofbauer cells: 85 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 60 nTPM
- white matter: 34 nTPM
- basal ganglia: 24 nTPM
- hippocampal formation: 21 nTPM
- midbrain: 14 nTPM
- hypothalamus: 13 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.69
- gnomAD pLI
- 0.1
- gnomAD missense Z
- 2.3
- DepMap mean gene effect
- 0.08
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads HS3ST2 as an antibody target. Whether an autoantibody or antibody against HS3ST2 could matter depends on whether native HS3ST2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
HS3ST2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label HS3ST2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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