Seroatlas · Human Serome Atlas

RAB40B

Ras-related protein Rab-40B

Also known as: RAR, RB40B_HUMAN, SEC4L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q12829
Gene: RAB40B
Ensembl: ENSG00000141542
Chromosome: 17
Canonical length: 278 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

The protein encoded by this gene has similarity to a yeast protein which suggests a role of the gene product in regulating secretory vesicles. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

278 residues, UniProt reviewed canonical sequence.

>Q12829|RAB40B
     1  MSALGSPVRA YDFLLKFLLV GDSDVGKGEI LASLQDGAAE SPYGHPAGID YKTTTILLDG
    61  RRVKLQLWDT SGQGRFCTIF RSYSRGAQGV ILVYDIANRW SFDGIDRWIK EIDEHAPGVP
   121  KILVGNRLHL AFKRQVPTEQ AQAYAERLGV TFFEVSPLCN FNITESFTEL ARIVLLRHGM
   181  DRLWRPSKVL SLQDLCCRAV VSCTPVHLVD KLPLPIALRS HLKSFSMANG LNARMMHGGS
   241  YSLTTSSTHK RSSLRKVKLV RPPQSPPKNC TRNSCKIS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB40B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 106 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 106 nTPM
spinal cord: 85 nTPM
amygdala: 74 nTPM
hippocampal formation: 70 nTPM
midbrain: 60 nTPM
cerebral cortex: 56 nTPM

Single-cell type

oligodendrocytes: 185 nCPM
endometrial glandular cells: 142 nCPM
epididymal clear cells: 131 nCPM
endometrial luminal cells: 124 nCPM
urothelial cells: 101 nCPM
colonocytes: 78 nCPM

Immune cell

plasmacytoid DC: 6.5 nTPM
non-classical monocyte: 3.4 nTPM
memory B-cell: 2.8 nTPM
NK-cell: 2 nTPM
T-reg: 1.8 nTPM
memory CD8 T-cell: 1.6 nTPM

Brain region

white matter: 107 nTPM
basal ganglia: 85 nTPM
cerebral cortex: 81 nTPM
medulla oblongata: 77 nTPM
midbrain: 69 nTPM
amygdala: 65 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.34
gnomAD pLI: 0
gnomAD missense Z: 0.46
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB40B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB40B as an antibody target. Whether an autoantibody or antibody against RAB40B could matter depends on whether native RAB40B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB40B is annotated at the cell surface, where native RAB40B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RAB40B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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