Seroatlas · Human Serome Atlas

TRIP13

Pachytene checkpoint protein 2 homolog

Also known as: 16E1BP, PCH2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15645
Gene
TRIP13
Ensembl
ENSG00000071539
Chromosome
5
Canonical length
432 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear speckles,Cytosol,Acrosome,Equatorial segment,Principal piece

OverviewNCBI Gene

This gene encodes a protein that interacts with thyroid hormone receptors, also known as hormone-dependent transcription factors. The gene product interacts specifically with the ligand binding domain. This gene is one of several that may play a role in early-stage non-small cell lung cancer. [provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

432 residues, UniProt reviewed canonical sequence.

>Q15645|TRIP13
     1  MDEAVGDLKQ ALPCVAESPT VHVEVHQRGS STAKKEDINL SVRKLLNRHN IVFGDYTWTE
    61  FDEPFLTRNV QSVSIIDTEL KVKDSQPIDL SACTVALHIF QLNEDGPSSE NLEEETENII
   121  AANHWVLPAA EFHGLWDSLV YDVEVKSHLL DYVMTTLLFS DKNVNSNLIT WNRVVLLHGP
   181  PGTGKTSLCK ALAQKLTIRL SSRYRYGQLI EINSHSLFSK WFSESGKLVT KMFQKIQDLI
   241  DDKDALVFVL IDEVESLTAA RNACRAGTEP SDAIRVVNAV LTQIDQIKRH SNVVILTTSN
   301  ITEKIDVAFV DRADIKQYIG PPSAAAIFKI YLSCLEELMK CQIIYPRQQL LTLRELEMIG
   361  FIENNVSKLS LLLNDISRKS EGLSGRVLRK LPFLAHALYV QAPTVTIEGF LQALSLAVDK
   421  QFEERKKLAA YI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIP13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
28 nTPM

Expression across tissuesHPA

Tissue

  • testis: 28 nTPM
  • thymus: 8.6 nTPM
  • tonsil: 7.9 nTPM
  • lymph node: 6.7 nTPM
  • fallopian tube: 6.3 nTPM
  • bone marrow: 5.7 nTPM

Single-cell type

  • late spermatids: 331 nCPM
  • early spermatids: 153 nCPM
  • early primary spermatocytes: 115 nCPM
  • respiratory ciliated cells: 89 nCPM
  • differentiating spermatogonia: 66 nCPM
  • fallopian tube ciliated cells: 61 nCPM

Immune cell

  • T-reg: 2.2 nTPM
  • NK-cell: 1.6 nTPM
  • naive B-cell: 1.2 nTPM
  • memory B-cell: 1.1 nTPM
  • plasmacytoid DC: 1 nTPM
  • memory CD8 T-cell: 0.7 nTPM

Brain region

  • basal ganglia: 2.6 nTPM
  • midbrain: 2.6 nTPM
  • hypothalamus: 2.3 nTPM
  • cerebral cortex: 2.1 nTPM
  • pons: 1.3 nTPM
  • amygdala: 1.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TRIP13.

Disease | AllUniProt

Conditions TRIP13 is implicated in, by any mechanism.

  • Mosaic variegated aneuploidy syndrome 3 (MVA3) MIM:617598
  • Oocyte/zygote/embryo maturation arrest 9 (OZEMA9) MIM:619011

Disease | GeneticClinVar

9 pathogenic / likely-pathogenic of 241 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Mosaic variegated aneuploidy syndrome 3
  • Oocyte maturation defect 9

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.25
gnomAD pLI
1
gnomAD missense Z
2.32
DepMap mean gene effect
-0.39
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRIP13 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIP13 as an antibody target. Whether an autoantibody or antibody against TRIP13 could matter depends on whether native TRIP13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIP13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIP13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRIP13. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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