Seroatlas · Human Serome Atlas

RAP2B

Ras-related protein Rap-2b

Also known as: RAP2B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P61225
Gene: RAP2B
Ensembl: ENSG00000181467
Chromosome: 3
Canonical length: 183 aa
Protein class: Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and palmitoylated. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

183 residues, UniProt reviewed canonical sequence.

>P61225|RAP2B
     1  MREYKVVVLG SGGVGKSALT VQFVTGSFIE KYDPTIEDFY RKEIEVDSSP SVLEILDTAG
    61  TEQFASMRDL YIKNGQGFIL VYSLVNQQSF QDIKPMRDQI IRVKRYERVP MILVGNKVDL
   121  EGEREVSYGE GKALAEEWSC PFMETSAKNK ASVDELFAEI VRQMNYAAQP NGDEGCCSAC
   181  VIL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAP2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 15 nTPM
esophagus: 14 nTPM
stomach: 8.2 nTPM
placenta: 8.1 nTPM
urinary bladder: 7.6 nTPM
spleen: 7.1 nTPM

Single-cell type

platelets: 811 nCPM
epididymal basal cells: 634 nCPM
ocular epithelial cells: 587 nCPM
urothelial cells: 398 nCPM
esophageal apical cells: 382 nCPM
suprabasal keratinocytes: 227 nCPM

Immune cell

basophil: 28 nTPM
intermediate monocyte: 28 nTPM
non-classical monocyte: 28 nTPM
gdT-cell: 20 nTPM
classical monocyte: 18 nTPM
memory CD8 T-cell: 17 nTPM

Brain region

hippocampal formation: 28 nTPM
hypothalamus: 20 nTPM
cerebral cortex: 18 nTPM
basal ganglia: 17 nTPM
white matter: 14 nTPM
midbrain: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.8
gnomAD pLI: 0.49
gnomAD missense Z: 2.25
DepMap mean gene effect: 0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAP2B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAP2B as an antibody target. Whether an autoantibody or antibody against RAP2B could matter depends on whether native RAP2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAP2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RAP2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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