DRG2

Protein identityUniProt · HPA

UniProt accession

P55039

Gene

DRG2

Ensembl

ENSG00000108591

Chromosome

17

Canonical length

364 aa

Protein class

Plasma proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Vesicles,Cytosol

OverviewNCBI Gene

This gene encodes a GTP-binding protein known to function in the regulation of cell growth and differentiation. Read-through transcripts containing this gene and a downstream gene have been identified, but they are not thought to encode a fusion protein. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jan 2012]

Canonical amino-acid sequenceUniProt

364 residues, UniProt reviewed canonical sequence.

>P55039|DRG2
     1  MGILEKISEI EKEIARTQKN KATEYHLGLL KAKLAKYRAQ LLEPSKSASS KGEGFDVMKS
    61  GDARVALIGF PSVGKSTFLS LMTSTASEAA SYEFTTLTCI PGVIEYKGAN IQLLDLPGII
   121  EGAAQGKGRG RQVIAVARTA DVIIMMLDAT KGEVQRSLLE KELESVGIRL NKHKPNIYFK
   181  PKKGGGISFN STVTLTQCSE KLVQLILHEY KIFNAEVLFR EDCSPDEFID VIVGNRVYMP
   241  CLYVYNKIDQ ISMEEVDRLA RKPNSVVISC GMKLNLDYLL EMLWEYLALT CIYTKKRGQR
   301  PDFTDAIILR KGASVEHVCH RIHRSLASQF KYALVWGTST KYSPQRVGLT HTMEHEDVIQ
   361  IVKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DRG2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.29

Highest tissue expression

36 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.89

gnomAD pLI

0

gnomAD missense Z

1.82

DepMap mean gene effect

-0.12

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cytoplasmic translation
• signal transduction

Molecular functions

• GTP binding
• GTPase activity
• metal ion binding
• RNA binding

Cellular components

• cytoplasm
• cytosol
• membrane
• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• TGS
• Small GTP-binding domain
• GTP binding domain
• GTP1/OBG, conserved site
• Beta-grasp domain superfamily
• TGS-like
• P-loop containing nucleoside triphosphate hydrolase
• OBG-type guanine nucleotide-binding (G) domain
• GTP binding protein, second domain
• Developmentally regulated GTP-binding protein
• 50S ribosome-binding GTPase
• TGS domain
• C-terminal region of MMR_HSR1 domain

KeywordsUniProt

• Cytoplasm
• GTP-binding
• Hydrolase
• Hydroxylation
• Magnesium
• Metal-binding
• Nucleotide-binding
• Nucleus
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of DRG2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• JMJD7
• RWDD1