Seroatlas · Human Serome Atlas

RAB12

Ras-related protein Rab-12

Also known as: RAB12_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6IQ22
Gene: RAB12
Canonical length: 244 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for RAB12 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

244 residues, UniProt reviewed canonical sequence.

>Q6IQ22|RAB12
     1  MDPGAALQRR AGGGGGLGAG SPALSGGQGR RRKQPPRPAD FKLQVIIIGS RGVGKTSLME
    61  RFTDDTFCEA CKSTVGVDFK IKTVELRGKK IRLQIWDTAG QERFNSITSA YYRSAKGIIL
   121  VYDITKKETF DDLPKWMKMI DKYASEDAEL LLVGNKLDCE TDREITRQQG EKFAQQITGM
   181  RFCEASAKDN FNVDEIFLKL VDDILKKMPL DILRNELSNS ILSLQPEPEI PPELPPPRPH
   241  VRCC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 180 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 180 nTPM
tongue: 99 nTPM
heart muscle: 80 nTPM
cerebellum: 37 nTPM
adipose tissue: 34 nTPM
blood vessel: 34 nTPM

Single-cell type

gonadotrophs: 138 nCPM
microglia: 129 nCPM
corticotrophs: 100 nCPM
thymic myoid cells: 98 nCPM
myonuclei: 89 nCPM
monocytes: 88 nCPM

Immune cell

basophil: 4.5 nTPM
non-classical monocyte: 2.4 nTPM
neutrophil: 1.7 nTPM
plasmacytoid DC: 1.7 nTPM
intermediate monocyte: 1.5 nTPM
NK-cell: 1.5 nTPM

Brain region

hypothalamus: 46 nTPM
cerebellum: 43 nTPM
cerebral cortex: 41 nTPM
basal ganglia: 38 nTPM
spinal cord: 37 nTPM
hippocampal formation: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.84
gnomAD pLI: 0.04
gnomAD missense Z: 1.69
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB12 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB12 as an antibody target. Whether an autoantibody or antibody against RAB12 could matter depends on whether native RAB12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RAB12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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