Seroatlas · Human Serome Atlas

URGCP

Up-regulator of cell proliferation

Also known as: DKFZp666G166, DKFZp686O0457, FLJ20654, KIAA1507, URG4, URGCP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TCY9
Gene: URGCP
Ensembl: ENSG00000106608
Chromosome: 7
Canonical length: 931 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Cytosol

OverviewNCBI Gene

URG4 is upregulated in the presence of hepatitis B virus (HBV)-encoded X antigen (HBxAg) and may contribute to the development of hepatocellular carcinoma by promoting hepatocellular growth and survival (Tufan et al., 2002 [PubMed 12082552]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

931 residues, UniProt reviewed canonical sequence.

>Q8TCY9|URGCP
     1  MASPGIEVEL LGKGHSDLGE VAPEIKASER RTAVAIADLE WREMEGDDCE FRYGDGTNEA
    61  QDNDFPTVER SRLQEMLSLL GLETYQVQKL SLQDSLQISF DSMKNWAPQV PKDLPWNFLR
   121  KLQALNADAR NTTMVLDVLP DARPVEKESQ MEEEIIYWDP ADDLAADIYS FSELPTPDTP
   181  VNPLDLLCAL LLSSDSFLQQ EIALKMALCQ FALPLVLPDS ENHYHTFLLW AMRGIVRTWW
   241  SQPPRGMGSF REDSVVLSRA PAFAFVRMDV SSNSKSQLLN AVLSPGHRQW DCFWHRDLNL
   301  GTNAREISDG LVEISWFFPS GREDLDIFPE PVAFLNLRGD IGSHWLQFKL LTEISSAVFI
   361  LTDNISKKEY KLLYSMKEST TKYYFILSPY RGKRNTNLRF LNKLIPVLKI DHSHVLVKVS
   421  STDSDSFVKR IRAIVGNVLR APCRRVSVED MAHAARKLGL KVDEDCEECQ KAKDRMERIT
   481  RKIKDSDAYR RDELRLQGDP WRKAAQVEKE FCQLQWAVDP PEKHRAELRR RLLELRMQQN
   541  GHDPSSGVQE FISGISSPSL SEKQYFLRWM EWGLARVAQP RLRQPPETLL TLRPKHGGTT
   601  DVGEPLWPEP LGVEHFLREM GQFYEAESCL VEAGRLPAGQ RRFAHFPGLA SELLLTGLPL
   661  ELIDGSTLSM PVRWVTGLLK ELHVRLERRS RLVVLSTVGV PGTGKSTLLN TMFGLRFATG
   721  KSCGPRGAFM QLITVAEGFS QDLGCDHILV IDSGGLIGGA LTSAGDRFEL EASLATLLMG
   781  LSNVTVISLA ETKDIPAAIL HAFLRLEKTG HMPNYQFVYQ NLHDVSVPGP RPRDKRQLLD
   841  PPGDLSRAAA QMEKQGDGFR ALAGLAFCDP EKQHIWHIPG LWHGAPPMAA VSLAYSEAIF
   901  ELKRCLLENI RNGLSNQNKN IQQLIELVRR L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against URGCP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 34 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 34 nTPM
cerebellum: 34 nTPM
skeletal muscle: 33 nTPM
tongue: 30 nTPM
liver: 29 nTPM
pituitary gland: 26 nTPM

Single-cell type

choroid plexus epithelial cells: 201 nCPM
brain excitatory neurons: 117 nCPM
brain inhibitory neurons: 116 nCPM
astrocytes: 96 nCPM
other brain neurons: 96 nCPM
bergmann glia: 88 nCPM

Immune cell

memory CD8 T-cell: 12 nTPM
T-reg: 11 nTPM
myeloid DC: 10 nTPM
naive CD4 T-cell: 9.9 nTPM
MAIT T-cell: 9.4 nTPM
memory CD4 T-cell: 9.2 nTPM

Brain region

cerebral cortex: 44 nTPM
basal ganglia: 43 nTPM
cerebellum: 42 nTPM
choroid plexus: 42 nTPM
hypothalamus: 40 nTPM
white matter: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.4
gnomAD pLI: 0.58
gnomAD missense Z: 2.32
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

GTP binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads URGCP as an antibody target. Whether an autoantibody or antibody against URGCP could matter depends on whether native URGCP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

URGCP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label URGCP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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