Seroatlas · Human Serome Atlas

ERAS

GTPase ERas

Also known as: HRAS2, HRASP, RASE_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z444
Gene: ERAS
Ensembl: ENSG00000187682
Chromosome: X
Canonical length: 233 aa
Protein class: Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a constitutively active member of the small GTPase Ras protein family. The encoded protein activates the phosphatidylinositol 3-kinase signal transduction pathway in undifferentiated stem cells, but is not expressed in differentiated cells. This gene may be involved in cancer and chemotherapy resistance. [provided by RefSeq, Dec 2012]

Canonical amino-acid sequenceUniProt

233 residues, UniProt reviewed canonical sequence.

>Q7Z444|ERAS
     1  MELPTKPGTF DLGLATWSPS FQGETHRAQA RRRDVGRQLP EYKAVVVGAS GVGKSALTIQ
    61  LNHQCFVEDH DPTIQDSYWK ELTLDSGDCI LNVLDTAGQA IHRALRDQCL AVCDGVLGVF
   121  ALDDPSSLIQ LQQIWATWGP HPAQPLVLVG NKCDLVTTAG DAHAAAAALA HSWGAHFVET
   181  SAKTRQGVEE AFSLLVHEIQ RVQEAMAKEP MARSCREKTR HQKATCHCGC SVA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ERAS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 3.2 nTPM

Expression across tissuesHPA

Tissue

hypothalamus: 3.2 nTPM
cerebellum: 2.5 nTPM
amygdala: 1.1 nTPM
basal ganglia: 1.1 nTPM
cerebral cortex: 1 nTPM
pituitary gland: 1 nTPM

Single-cell type

paneth cells: 3.9 nCPM
sertoli cells: 3.4 nCPM
early primary spermatocytes: 2.8 nCPM
differentiating spermatogonia: 2.2 nCPM
other brain neurons: 2.2 nCPM
astrocytes: 1.5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 4.3 nTPM
basal ganglia: 1.6 nTPM
cerebral cortex: 1.6 nTPM
midbrain: 1.5 nTPM
cerebellum: 1.2 nTPM
medulla oblongata: 1.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.45
gnomAD pLI: 0.22
gnomAD missense Z: 1.48
DepMap mean gene effect: 0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Ras protein signal transduction

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ERAS in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PIK3CD

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ERAS as an antibody target. Whether an autoantibody or antibody against ERAS could matter depends on whether native ERAS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ERAS is annotated at the cell surface, where native ERAS is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ERAS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...