Seroatlas · Human Serome Atlas

DDX5

Probable ATP-dependent RNA helicase DDX5

Also known as: DDX5_HUMAN, G17P1, HLR1, p68

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P17844
Gene
DDX5
Ensembl
ENSG00000108654
Chromosome
17
Canonical length
614 aa
Protein class
Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli

OverviewNCBI Gene

This gene encodes a member of the DEAD box family of RNA helicases that are involved in a variety of cellular processes as a result of its role as an adaptor molecule, promoting interactions with a large number of other factors. This protein is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. Members of this family contain nine conserved motifs, including the conserved Asp-Glu-Ala-Asp (DEAD) motif, important to ATP binding and hydrolysis as well as RNA binding and unwinding activities. Dysregulation of this gene may play a role in cancer development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2017]

Canonical amino-acid sequenceUniProt

614 residues, UniProt reviewed canonical sequence.

>P17844|DDX5
     1  MSGYSSDRDR GRDRGFGAPR FGGSRAGPLS GKKFGNPGEK LVKKKWNLDE LPKFEKNFYQ
    61  EHPDLARRTA QEVETYRRSK EITVRGHNCP KPVLNFYEAN FPANVMDVIA RQNFTEPTAI
   121  QAQGWPVALS GLDMVGVAQT GSGKTLSYLL PAIVHINHQP FLERGDGPIC LVLAPTRELA
   181  QQVQQVAAEY CRACRLKSTC IYGGAPKGPQ IRDLERGVEI CIATPGRLID FLECGKTNLR
   241  RTTYLVLDEA DRMLDMGFEP QIRKIVDQIR PDRQTLMWSA TWPKEVRQLA EDFLKDYIHI
   301  NIGALELSAN HNILQIVDVC HDVEKDEKLI RLMEEIMSEK ENKTIVFVET KRRCDELTRK
   361  MRRDGWPAMG IHGDKSQQER DWVLNEFKHG KAPILIATDV ASRGLDVEDV KFVINYDYPN
   421  SSEDYIHRIG RTARSTKTGT AYTFFTPNNI KQVSDLISVL REANQAINPK LLQLVEDRGS
   481  GRSRGRGGMK DDRRDRYSAG KRGGFNTFRD RENYDRGYSS LLKRDFGAKT QNGVYSAANY
   541  TNGSFGSNFV SAGIQTSFRT GNPTGTYQNG YDSTQQYGSN VPNMHNGMNQ QAYAYPATAA
   601  APMIGYPMPT GYSQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DDX5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
256 nTPM

Expression across tissuesHPA

Tissue

  • smooth muscle: 256 nTPM
  • thymus: 254 nTPM
  • urinary bladder: 213 nTPM
  • bone marrow: 207 nTPM
  • retina: 196 nTPM
  • cervix: 179 nTPM

Single-cell type

  • pituicytes/fscs: 1,391 nCPM
  • endometrial secretory cells: 1,385 nCPM
  • epididymal basal cells: 1,308 nCPM
  • ocular epithelial cells: 1,232 nCPM
  • endometrial luminal cells: 1,202 nCPM
  • breast lactating cells: 1,129 nCPM

Immune cell

  • total PBMC: 320 nTPM
  • basophil: 233 nTPM
  • non-classical monocyte: 198 nTPM
  • eosinophil: 171 nTPM
  • classical monocyte: 161 nTPM
  • MAIT T-cell: 150 nTPM

Brain region

  • choroid plexus: 269 nTPM
  • white matter: 215 nTPM
  • cerebellum: 205 nTPM
  • cerebral cortex: 196 nTPM
  • thalamus: 193 nTPM
  • medulla oblongata: 192 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.1
gnomAD pLI
1
gnomAD missense Z
2.76
DepMap mean gene effect
-0.78
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DDX5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DDX5 as an antibody target. Whether an autoantibody or antibody against DDX5 could matter depends on whether native DDX5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DDX5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DDX5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DDX5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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