Seroatlas · Human Serome Atlas

ABCB10

ATP-binding cassette sub-family B member 10, mitochondrial

Also known as: ABCBA_HUMAN, EST20237, M-ABC2, MTABC2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NRK6
Gene
ABCB10
Ensembl
ENSG00000135776
Chromosome
1
Canonical length
738 aa
Protein class
Plasma proteins, Predicted membrane proteins, Transporters
Quaternary structure
Homodimer

OverviewNCBI Gene

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The function of this mitochondrial protein is unknown. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

738 residues, UniProt reviewed canonical sequence.

>Q9NRK6|ABCB10
     1  MRGPPAWPLR LLEPPSPAEP GRLLPVACVW AAASRVPGSL SPFTGLRPAR LWGAGPALLW
    61  GVGAARRWRS GCRGGGPGAS RGVLGLARLL GLWARGPGSC RCGAFAGPGA PRLPRARFPG
   121  GPAAAAWAGD EAWRRGPAAP PGDKGRLRPA AAGLPEARKL LGLAYPERRR LAAAVGFLTM
   181  SSVISMSAPF FLGKIIDVIY TNPTVDYSDN LTRLCLGLSA VFLCGAAANA IRVYLMQTSG
   241  QRIVNRLRTS LFSSILRQEV AFFDKTRTGE LINRLSSDTA LLGRSVTENL SDGLRAGAQA
   301  SVGISMMFFV SPNLATFVLS VVPPVSIIAV IYGRYLRKLT KVTQDSLAQA TQLAEERIGN
   361  VRTVRAFGKE MTEIEKYASK VDHVMQLARK EAFARAGFFG ATGLSGNLIV LSVLYKGGLL
   421  MGSAHMTVGE LSSFLMYAFW VGISIGGLSS FYSELMKGLG AGGRLWELLE REPKLPFNEG
   481  VILNEKSFQG ALEFKNVHFA YPARPEVPIF QDFSLSIPSG SVTALVGPSG SGKSTVLSLL
   541  LRLYDPASGT ISLDGHDIRQ LNPVWLRSKI GTVSQEPILF SCSIAENIAY GADDPSSVTA
   601  EEIQRVAEVA NAVAFIRNFP QGFNTVVGEK GVLLSGGQKQ RIAIARALLK NPKILLLDEA
   661  TSALDAENEY LVQEALDRLM DGRTVLVIAH RLSTIKNANM VAVLDQGKIT EYGKHEELLS
   721  KPNGIYRKLM NKQSFISA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ABCB10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
57 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 57 nTPM
  • liver: 18 nTPM
  • duodenum: 16 nTPM
  • small intestine: 13 nTPM
  • skeletal muscle: 12 nTPM
  • cerebellum: 11 nTPM

Single-cell type

  • erythrocyte progenitors: 338 nCPM
  • neutrophil progenitors: 73 nCPM
  • monocyte progenitors: 68 nCPM
  • myonuclei: 64 nCPM
  • erythrocytes: 63 nCPM
  • megakaryocyte-erythroid progenitors: 46 nCPM

Immune cell

  • memory CD8 T-cell: 1.1 nTPM
  • MAIT T-cell: 1 nTPM
  • naive CD8 T-cell: 1 nTPM
  • eosinophil: 0.9 nTPM
  • memory CD4 T-cell: 0.9 nTPM
  • plasmacytoid DC: 0.9 nTPM

Brain region

  • cerebellum: 13 nTPM
  • white matter: 10 nTPM
  • thalamus: 9.9 nTPM
  • choroid plexus: 9.2 nTPM
  • cerebral cortex: 8.9 nTPM
  • medulla oblongata: 8.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.94
gnomAD pLI
0
gnomAD missense Z
1.35
DepMap mean gene effect
0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ABCB10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ABCB10 as an antibody target. Whether an autoantibody or antibody against ABCB10 could matter depends on whether native ABCB10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ABCB10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ABCB10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ABCB10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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