Seroatlas · Human Serome Atlas

MYO1G

Unconventional myosin-Ig

Also known as: HA-2, MYO1G_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: B0I1T2
Gene: MYO1G
Ensembl: ENSG00000136286
Chromosome: 7
Canonical length: 1018 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane

OverviewNCBI Gene

MYO1G is a plasma membrane-associated class I myosin (see MIM 601478) that is abundant in T and B lymphocytes and mast cells (Pierce et al., 2001 [PubMed 11544309]; Patino-Lopez et al., 2010 [PubMed 20071333]).[supplied by OMIM, Jun 2010]

Canonical amino-acid sequenceUniProt

1018 residues, UniProt reviewed canonical sequence.

>B0I1T2|MYO1G
     1  MEDEEGPEYG KPDFVLLDQV TMEDFMRNLQ LRFEKGRIYT YIGEVLVSVN PYQELPLYGP
    61  EAIARYQGRE LYERPPHLYA VANAAYKAMK HRSRDTCIVI SGESGAGKTE ASKHIMQYIA
   121  AVTNPSQRAE VERVKDVLLK STCVLEAFGN ARTNRNHNSS RFGKYMDINF DFKGDPIGGH
   181  IHSYLLEKSR VLKQHVGERN FHAFYQLLRG SEDKQLHELH LERNPAVYNF THQGAGLNMT
   241  VHSALDSDEQ SHQAVTEAMR VIGFSPEEVE SVHRILAAIL HLGNIEFVET EEGGLQKEGL
   301  AVAEEALVDH VAELTATPRD LVLRSLLART VASGGRELIE KGHTAAEASY ARDACAKAVY
   361  QRLFEWVVNR INSVMEPRGR DPRRDGKDTV IGVLDIYGFE VFPVNSFEQF CINYCNEKLQ
   421  QLFIQLILKQ EQEEYEREGI TWQSVEYFNN ATIVDLVERP HRGILAVLDE ACSSAGTITD
   481  RIFLQTLDMH HRHHLHYTSR QLCPTDKTME FGRDFRIKHY AGDVTYSVEG FIDKNRDFLF
   541  QDFKRLLYNS TDPTLRAMWP DGQQDITEVT KRPLTAGTLF KNSMVALVEN LASKEPFYVR
   601  CIKPNEDKVA GKLDENHCRH QVAYLGLLEN VRVRRAGFAS RQPYSRFLLR YKMTCEYTWP
   661  NHLLGSDKAA VSALLEQHGL QGDVAFGHSK LFIRSPRTLV TLEQSRARLI PIIVLLLQKA
   721  WRGTLARWRC RRLRAIYTIM RWFRRHKVRA HLAELQRRFQ AARQPPLYGR DLVWPLPPAV
   781  LQPFQDTCHA LFCRWRARQL VKNIPPSDMP QIKAKVAAMG ALQGLRQDWG CRRAWARDYL
   841  SSATDNPTAS SLFAQRLKTL QDKDGFGAVL FSSHVRKVNR FHKIRNRALL LTDQHLYKLD
   901  PDRQYRVMRA VPLEAVTGLS VTSGGDQLVV LHARGQDDLV VCLHRSRPPL DNRVGELVGV
   961  LAAHCQGEGR TLEVRVSDCI PLSHRGVRRL ISVEPRPEQP EPDFRCARGS FTLLWPSR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MYO1G can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 41 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 41 nTPM
thymus: 25 nTPM
lymph node: 24 nTPM
spleen: 22 nTPM
appendix: 16 nTPM
tonsil: 14 nTPM

Single-cell type

monocytes: 154 nCPM
monocyte progenitors: 99 nCPM
nk-cells: 69 nCPM
t-cells: 61 nCPM
thymocytes: 53 nCPM
neutrophil progenitors: 48 nCPM

Immune cell

non-classical monocyte: 130 nTPM
intermediate monocyte: 96 nTPM
T-reg: 80 nTPM
total PBMC: 80 nTPM
gdT-cell: 62 nTPM
classical monocyte: 58 nTPM

Brain region

thalamus: 3.1 nTPM
medulla oblongata: 2.1 nTPM
hypothalamus: 1.6 nTPM
white matter: 1.2 nTPM
cerebral cortex: 1.1 nTPM
spinal cord: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.65
gnomAD pLI: 0
gnomAD missense Z: 1.86
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

actin filament organization
actin filament-based movement
cell-substrate adhesion
endocytosis
establishment of localization in cell
exocytosis
Fc-gamma receptor signaling pathway involved in phagocytosis
T cell mediated immunity
T cell migration
cell gliding
T cell meandering migration

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MYO1G as an antibody target. Whether an autoantibody or antibody against MYO1G could matter depends on whether native MYO1G is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MYO1G is annotated at the cell surface, where native MYO1G is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MYO1G as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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