Seroatlas · Human Serome Atlas

SULT4A1

Sulfotransferase 4A1

Also known as: hBR-STL-1, ST4A1_HUMAN, SULTX3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BR01
Gene: SULT4A1
Ensembl: ENSG00000130540
Chromosome: 22
Canonical length: 284 aa
Protein class: Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the sulfotransferase family. The encoded protein is a brain-specific sulfotransferase believed to be involved in the metabolism of neurotransmitters. Polymorphisms in this gene may be associated with susceptibility to schizophrenia. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

284 residues, UniProt reviewed canonical sequence.

>Q9BR01|SULT4A1
     1  MAESEAETPS TPGEFESKYF EFHGVRLPPF CRGKMEEIAN FPVRPSDVWI VTYPKSGTSL
    61  LQEVVYLVSQ GADPDEIGLM NIDEQLPVLE YPQPGLDIIK ELTSPRLIKS HLPYRFLPSD
   121  LHNGDSKVIY MARNPKDLVV SYYQFHRSLR TMSYRGTFQE FCRRFMNDKL GYGSWFEHVQ
   181  EFWEHRMDSN VLFLKYEDMH RDLVTMVEQL ARFLGVSCDK AQLEALTEHC HQLVDQCCNA
   241  EALPVGRGRV GLWKDIFTVS MNEKFDLVYK QKMGKCDLTF DFYL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SULT4A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 96 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 96 nTPM
cerebellum: 61 nTPM
hypothalamus: 38 nTPM
hippocampal formation: 28 nTPM
basal ganglia: 27 nTPM
amygdala: 24 nTPM

Single-cell type

other brain neurons: 65 nCPM
retinal pigment epithelial cells: 64 nCPM
brain excitatory neurons: 63 nCPM
brain inhibitory neurons: 62 nCPM
retinal amacrine cells: 60 nCPM
late spermatids: 48 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 284 nTPM
white matter: 141 nTPM
hypothalamus: 129 nTPM
basal ganglia: 121 nTPM
hippocampal formation: 107 nTPM
pons: 97 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.32
gnomAD pLI: 0.97
gnomAD missense Z: 2.66
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SULT4A1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

MAPK8IP3

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SULT4A1 as an antibody target. Whether an autoantibody or antibody against SULT4A1 could matter depends on whether native SULT4A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SULT4A1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SULT4A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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