Seroatlas · Human Serome Atlas

KATNA1

Katanin p60 ATPase-containing subunit A1

Also known as: KTNA1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75449
Gene
KATNA1
Ensembl
ENSG00000186625
Chromosome
6
Canonical length
491 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Centriolar satellite
Quaternary structure
Homooligomer

OverviewNCBI Gene

Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2011]

Canonical amino-acid sequenceUniProt

491 residues, UniProt reviewed canonical sequence.

>O75449|KATNA1
     1  MSLLMISENV KLAREYALLG NYDSAMVYYQ GVLDQMNKYL YSVKDTYLQQ KWQQVWQEIN
    61  VEAKHVKDIM KTLESFKLDS TPLKAAQHDL PASEGEVWSM PVPVERRPSP GPRKRQSSQY
   121  SDPKSHGNRP STTVRVHRSS AQNVHNDRGK AVRCREKKEQ NKGREEKNKS PAAVTEPETN
   181  KFDSTGYDKD LVEALERDII SQNPNVRWDD IADLVEAKKL LKEAVVLPMW MPEFFKGIRR
   241  PWKGVLMVGP PGTGKTLLAK AVATECKTTF FNVSSSTLTS KYRGESEKLV RLLFEMARFY
   301  SPATIFIDEI DSICSRRGTS EEHEASRRVK AELLVQMDGV GGTSENDDPS KMVMVLAATN
   361  FPWDIDEALR RRLEKRIYIP LPSAKGREEL LRISLRELEL ADDVDLASIA ENMEGYSGAD
   421  ITNVCRDASL MAMRRRIEGL TPEEIRNLSK EEMHMPTTME DFEMALKKVS KSVSAADIER
   481  YEKWIFEFGS C

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KATNA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
42 nTPM

Expression across tissuesHPA

Tissue

  • testis: 42 nTPM
  • skeletal muscle: 23 nTPM
  • ovary: 21 nTPM
  • bone marrow: 18 nTPM
  • choroid plexus: 18 nTPM
  • blood vessel: 16 nTPM

Single-cell type

  • early spermatids: 463 nCPM
  • late spermatids: 278 nCPM
  • late primary spermatocytes: 275 nCPM
  • rod photoreceptor cells: 116 nCPM
  • early primary spermatocytes: 101 nCPM
  • cone photoreceptor cells: 87 nCPM

Immune cell

  • basophil: 40 nTPM
  • T-reg: 34 nTPM
  • eosinophil: 29 nTPM
  • intermediate monocyte: 29 nTPM
  • memory B-cell: 28 nTPM
  • myeloid DC: 26 nTPM

Brain region

  • choroid plexus: 19 nTPM
  • cerebellum: 13 nTPM
  • white matter: 13 nTPM
  • medulla oblongata: 11 nTPM
  • basal ganglia: 11 nTPM
  • pons: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.7
gnomAD pLI
0
gnomAD missense Z
1.74
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KATNA1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KATNA1 as an antibody target. Whether an autoantibody or antibody against KATNA1 could matter depends on whether native KATNA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KATNA1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KATNA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KATNA1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...