Seroatlas · Human Serome Atlas

UTP25

U3 small nucleolar RNA-associated protein 25 homolog

Also known as: C1orf107, DEF, DIEXF, MGC29875, UTP25_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q68CQ4
Gene: UTP25
Ensembl: ENSG00000117597
Chromosome: 1
Canonical length: 756 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables RNA binding activity. Involved in several processes, including protein catabolic process; protein destabilization; and protein localization to nucleolus. Located in nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

756 residues, UniProt reviewed canonical sequence.

>Q68CQ4|UTP25
     1  MGKRGSRSQS QLLNTLTKKQ KKHLRDFGEE HPFYDRVSRK EAKPQICQLS ESSDSSDSES
    61  DSESEPQQVS GYHRLLATLK NVSEEEEEDE EEEEEEDSIV DDAEMNDEDG GSDVSVEEEM
   121  AAESTESPEN VALSADPEGK EDGEEPPGTS QTSPEEFTDA KHESLFSLET NFLEEESGDN
   181  SSLKASQDPF LQHVNKELKE KAIQAVATNP KTTHELKWPI LGQLFFSSKF QKLETFKPPK
   241  DIDLKSLHLQ KPLESTWTKT NSQFLSGPQK SSSPFTPLQK ELFLIMNSYR DLFYPERTAL
   301  KNGEEIRHVY CLHVINHILK ANAQVLGNNS RRRSQKFGVG DDDDFRDQGL TRPKVLIVVP
   361  FREAALRVVQ LFISLLEGDS KKKIIVSNKK RFQGEYGSDP EERPPNLKRP EDYEAVFVGN
   421  IDDHFRIGVA ILQRSIRLYA PFYSSDILIA SPLGLRTIIG GEGEKKRDFD FLSSIELLII
   481  DQADIYLMQN WEHVLHLMNH MNLLPLDSHG VDFSRVRMWS LNNWSKYYRQ TLLFGALQDA
   541  QINSVFNKYC VNMQGQVAVR NVPMTGSISH VLVQLPHVFQ RMEAENLASV IDARFNFFVN
   601  KILPQYRDAV MSHTLIYIPS YFDFVRLRNY FKKEELNFTH ICEYTQKSGV SRARHFFLQG
   661  EKQFLLFTER FHFYKRYTIK GIRNLIFYEL PTYPHFYSEI CNMLRATNRG EEATWTCTVL
   721  YSKYDAQRLA AVVGVERAAQ MLQSNKNVHL FITGEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UTP25 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 6.1 nTPM

Expression across tissuesHPA

Tissue

breast: 6.1 nTPM
ovary: 5.3 nTPM
lymph node: 4.6 nTPM
skin: 4.4 nTPM
tonsil: 4.4 nTPM
fallopian tube: 4.2 nTPM

Single-cell type

adrenal medulla cells: 43 nCPM
ocular epithelial cells: 29 nCPM
pancreatic acinar cells: 29 nCPM
erythrocyte progenitors: 27 nCPM
adrenal cortex cells: 25 nCPM
basal keratinocytes: 22 nCPM

Immune cell

memory B-cell: 5.3 nTPM
MAIT T-cell: 5 nTPM
naive CD4 T-cell: 5 nTPM
NK-cell: 4.9 nTPM
naive B-cell: 4.5 nTPM
naive CD8 T-cell: 4.5 nTPM

Brain region

cerebral cortex: 9.9 nTPM
basal ganglia: 9.8 nTPM
white matter: 9.4 nTPM
hypothalamus: 8.5 nTPM
amygdala: 8.4 nTPM
midbrain: 8.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.68
gnomAD pLI: 0
DepMap mean gene effect: -0.94
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

P-loop containing nucleoside triphosphate hydrolase
U3 small nucleolar RNA-associated protein 25
UTP25, C-terminal domain
UTP25, NTP hydrolase-like domain
Utp25, C-terminal domain
UTP25, NTP hydrolase-like domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UTP25 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UTP25 as an antibody target. Whether an autoantibody or antibody against UTP25 could matter depends on whether native UTP25 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UTP25 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UTP25 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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