GNL3L

Protein identityUniProt · HPA

UniProt accession

Q9NVN8

Gene

GNL3L

Ensembl

ENSG00000130119

Chromosome

X

Canonical length

582 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Nucleoli,Cytosol

Quaternary structure

Homodimer

OverviewNCBI Gene

The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

582 residues, UniProt reviewed canonical sequence.

>Q9NVN8|GNL3L
     1  MMKLRHKNKK PGEGSKGHKK ISWPYPQPAK QNGKKATSKV PSAPHFVHPN DHANREAELK
    61  KKWVEEMREK QQAAREQERQ KRRTIESYCQ DVLRRQEEFE HKEEVLQELN MFPQLDDEAT
   121  RKAYYKEFRK VVEYSDVILE VLDARDPLGC RCFQMEEAVL RAQGNKKLVL VLNKIDLVPK
   181  EVVEKWLDYL RNELPTVAFK ASTQHQVKNL NRCSVPVDQA SESLLKSKAC FGAENLMRVL
   241  GNYCRLGEVR THIRVGVVGL PNVGKSSLIN SLKRSRACSV GAVPGITKFM QEVYLDKFIR
   301  LLDAPGIVPG PNSEVGTILR NCVHVQKLAD PVTPVETILQ RCNLEEISNY YGVSGFQTTE
   361  HFLTAVAHRL GKKKKGGLYS QEQAAKAVLA DWVSGKISFY IPPPATHTLP THLSAEIVKE
   421  MTEVFDIEDT EQANEDTMEC LATGESDELL GDTDPLEMEI KLLHSPMTKI ADAIENKTTV
   481  YKIGDLTGYC TNPNRHQMGW AKRNVDHRPK SNSMVDVCSV DRRSVLQRIM ETDPLQQGQA
   541  LASALKNKKK MQKRADKIAS KLSDSMMSAL DLSGNADDGV GD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GNL3L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.39

Highest tissue expression

8.3 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GNL3L.

Disease | ImmuneIEDB

Conditions an epitope on GNL3L was assayed in.

• skin melanoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.23

gnomAD pLI

1

gnomAD missense Z

1.36

DepMap mean gene effect

-0.91

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• negative regulation of protein sumoylation
• negative regulation of protein ubiquitination
• negative regulation of telomere maintenance via telomerase
• positive regulation of protein localization to chromosome, telomeric region
• positive regulation of protein-containing complex assembly
• regulation of protein stability
• ribosome biogenesis

Molecular functions

• GTP binding
• RNA binding

Cellular components

• cytosol
• membrane
• nucleolus
• nucleoplasm
• telomerase holoenzyme complex

Protein domainsUniProt · Pfam · InterPro

• GTP binding domain
• GTP-binding protein, orthogonal bundle domain superfamily
• P-loop containing nucleoside triphosphate hydrolase
• Circularly permuted (CP)-type guanine nucleotide-binding (G) domain
• TRAFAC YlqF/YawG GTPases, Ribosome Maturation
• 50S ribosome-binding GTPase

KeywordsUniProt

• Coiled coil
• GTP-binding
• Isopeptide bond
• Nucleotide-binding
• Nucleus
• Ribosome biogenesis
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of GNL3L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MDM2
• TERF1
• TERT
• TP53