KIF26B

Protein identityUniProt · HPA

UniProt accession

Q2KJY2

Gene

KIF26B

Ensembl

ENSG00000162849

Chromosome

1

Canonical length

2108 aa

Protein class

Predicted intracellular proteins

Subcellular location

Plasma membrane,Microtubules,Primary cilium

OverviewNCBI Gene

The protein encoded by this gene is an intracellular motor protein thought to transport organelles along microtubules. The encoded protein is required for kidney development. Elevated levels of this protein have been found in some breast and colorectal cancers. [provided by RefSeq, Mar 2017]

Canonical amino-acid sequenceUniProt

2108 residues, UniProt reviewed canonical sequence.

>Q2KJY2|KIF26B
     1  MNSVAGNKER LAVSTRGKKY GVNEVCSPTK PAAPFSPESW YRKAYEESRA GSRPTPEGAG
    61  SALGSSGTPS PGSGTSSPSS FTGSPGPASP GIGTSSPGSL GGSPGFGTGS PGSGSGGGSS
   121  PGSDRGVWCE NCNARLVELK RQALRLLLPG PFPGKDPAFS AVIHDKLQVP NTIRKAWNDR
   181  DNRCDICATH LNQLKQEAIQ MVLTLEQAAG SEHYDASPCS PPPLSNIPTL VGSRHVGGLQ
   241  QPRDWAFVPA PCATSNYTGF ANKHGSKPSS LGVSNGAEKK SGSPTHQAKV SLQMATSPSN
   301  GNILNSVAIQ AHQYLDGTWS LSRTNGVTLY PYQISQLMTE SSREGLTEAV LNRYNADKPS
   361  ACSVPASQGS CVASETSTGT SVAASFFARA AQKLNLSSKK KKHRPSTSSA AEPPLFATSF
   421  SGILQTSPPP APPCLLRAVN KVKDTPGLGK VKVMLRICST LARDTSESSS FLKVDPRKKQ
   481  ITLYDPLTCG GQNAFQKRGN QVPPKMFAFD AVFPQDASQA EVCAGTVAEV IQSVVNGADG
   541  CVFCFGHAKL GKSYTMIGKD DSMQNLGIIP CAISWLFKLI NERKEKTGAR FSVRVSAVEV
   601  WGKEENLRDL LSEVATGSLQ DGQSPGVYLC EDPICGTQLQ NQSELRAPTA EKAAFFLDAA
   661  IASRRSHQQD CDEDDHRNSH VFFTLHIYQY RMEKSGKGGM SGGRSRLHLI DLGSCVKALS
   721  KNREGGSGLC LSLSALGNVI LALVNGSKHI PYKESKLAML LRESLGNMNC RTTMIAHISA
   781  AVGSYAETLS TIQIASRVLR MKKKKTKYTS SSSGGESSCE EGRMRRPTQL RPFHTRATVD
   841  PDFPIAHLSS DPDYSSSSEQ SCDTVIYIGP NGTALSDKEL TDNEGPPDFV PIVPALQKTR
   901  GDSRPAEAGE AAAGKSERDC LKCNTFAELQ ERLDCIDGSE EPSSFPFEEL PAQFGPEQAS
   961  RGPRLSQAAG ASPLSESDKE DNGSEGQLTN REGPELPASK MQRSHSPVPA AAPAHSPSPA
  1021  SPRSVPGSSS QHSASPLVQS PSLQSSRESL NSCGFVEGKP RPMGSPRLGI ASLSKTSEYK
  1081  PPSSPSQRCK VYTQKGVLPS PAPLPPSSKD SGVASRESLL QPEVRTPPVG MSPQVLKKSM
  1141  SAGSEGFPET PVDDEQQAAT PSESKKEILS TTMVTVQQPL ELNGEDELVF TLVEELTISG
  1201  VLDSGRPTSI ISFNSDCSAR ALASGSRPVS IISSISEDLE CYSSTAPVSE VSITQFLPLP
  1261  KMSLDEKAQD AGSRRSSISS WLSEMSAGSE GEQSCHSFIA QTCFGHGEAM AEPVASEFVS
  1321  SLQNTAVVCR EKPKASPDNL LILSEMGDDS FNKAAPIKGC KISTVSKAMV TISNTANLSS
  1381  CEGYIPMKTN ITVYPCIAMS PRNIQEPEAP TATPKAGPTL AQSRESKENS AKKEMKFEDP
  1441  WLKREEEVKK ETAHPNEEGM MRCETATGPS NAETRAEQEQ DGKPSPGDRL SSSSGEVSAS
  1501  PVTDNFRRVV DGCEMALPGL ATQSPVHPNK SVKSSSLPRA FQKASRQEEP DSLSYYCAAE
  1561  TNGVGAASGT PPSKATLEGK VASPKHCVLA RPKGTPPLPP VRKSSLDQKN RASPQHSASG
  1621  SGTSSPLNQP AAFPAGLPDE PSGKTKDASS SSKLFSAKLE QLASRSNSLG RATVSHYECL
  1681  SLERAESLSS VSSRLHAGKD GTMPRAGRSL GRSAGTSPPS SGASPKAGQS KISAVSRLLL
  1741  ASPRARGPSA STTKTLSFST KSLPQAVGQG SSSPPGGKHT PWSTQSLSRN RSSGLASKLP
  1801  LRAVSGRISE LLQGGAGARG LQLRAGPEAE ARGGALAEDE PAAAHLLPSP YSKITPPRRP
  1861  HRCSSGHGSD NSSVLSGELP PAMGKTALFY HSGGSSGYES VMRDSEATGS ASSAQDSTSE
  1921  NSSSVGGRCR SLKTPKKRSN PGSQRRRLIP ALSLDTSSPV RKPPNSTGVR WVDGPLRSSP
  1981  RGLGEPFEIK VYEIDDVERL QRRRGGASKE AMCFNAKLKI LEHRQQRIAE VRAKYEWLMK
  2041  ELEATKQYLM LDPNKWLSEF DLEQVWELDS LEYLEALECV TERLESRVNF CKAHLMMITC
  2101  FDITSRRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIF26B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.59

Highest tissue expression

3.4 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.21

gnomAD pLI

1

gnomAD missense Z

0.95

DepMap mean gene effect

-0.08

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• establishment of cell polarity
• microtubule-based movement
• positive regulation of cell-cell adhesion
• ureteric bud invasion

Molecular functions

• ATP binding
• microtubule binding
• microtubule motor activity

Cellular components

• cytoplasm
• microtubule

Protein domainsUniProt · Pfam · InterPro

• Kinesin motor domain
• P-loop containing nucleoside triphosphate hydrolase
• Kinesin-like protein
• Kinesin motor domain superfamily
• Kinesin-like protein KIF26A/B, helical domain
• Kinesin motor domain
• Kinesin-like protein KIF26A/B, tri-helical

KeywordsUniProt

• ATP-binding
• Cytoplasm
• Cytoskeleton
• Developmental protein
• Microtubule
• Motor protein
• Nucleotide-binding
• Phosphoprotein
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of KIF26B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MYH10