Seroatlas · Human Serome Atlas

CDC6

Cell division control protein 6 homolog

Also known as: CDC18L, CDC6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q99741
Gene
CDC6
Ensembl
ENSG00000094804
Chromosome
17
Canonical length
560 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytokinetic bridge,Mitotic spindle,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

560 residues, UniProt reviewed canonical sequence.

>Q99741|CDC6
     1  MPQTRSQAQA TISFPKRKLS RALNKAKNSS DAKLEPTNVQ TVTCSPRVKA LPLSPRKRLG
    61  DDNLCNTPHL PPCSPPKQGK KENGPPHSHT LKGRRLVFDN QLTIKSPSKR ELAKVHQNKI
   121  LSSVRKSQEI TTNSEQRCPL KKESACVRLF KQEGTCYQQA KLVLNTAVPD RLPAREREMD
   181  VIRNFLREHI CGKKAGSLYL SGAPGTGKTA CLSRILQDLK KELKGFKTIM LNCMSLRTAQ
   241  AVFPAIAQEI CQEEVSRPAG KDMMRKLEKH MTAEKGPMIV LVLDEMDQLD SKGQDVLYTL
   301  FEWPWLSNSH LVLIGIANTL DLTDRILPRL QAREKCKPQL LNFPPYTRNQ IVTILQDRLN
   361  QVSRDQVLDN AAVQFCARKV SAVSGDVRKA LDVCRRAIEI VESDVKSQTI LKPLSECKSP
   421  SEPLIPKRVG LIHISQVISE VDGNRMTLSQ EGAQDSFPLQ QKILVCSLML LIRQLKIKEV
   481  TLGKLYEAYS KVCRKQQVAA VDQSECLSLS GLLEARGILG LKRNKETRLT KVFFKIEEKE
   541  IEHALKDKAL IGNILATGLP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDC6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 26 nTPM
  • tonsil: 16 nTPM
  • thymus: 16 nTPM
  • lymph node: 15 nTPM
  • appendix: 13 nTPM
  • testis: 9.4 nTPM

Single-cell type

  • early primary spermatocytes: 120 nCPM
  • erythrocyte progenitors: 69 nCPM
  • oocytes: 60 nCPM
  • extravillous trophoblasts: 40 nCPM
  • megakaryocyte progenitors: 39 nCPM
  • migrating cytotrophoblasts: 36 nCPM

Immune cell

  • plasmacytoid DC: 3.6 nTPM
  • T-reg: 2.4 nTPM
  • NK-cell: 1.5 nTPM
  • memory CD8 T-cell: 1.1 nTPM
  • naive CD8 T-cell: 1.1 nTPM
  • gdT-cell: 0.8 nTPM

Brain region

  • cerebral cortex: 5.4 nTPM
  • basal ganglia: 3.2 nTPM
  • white matter: 3 nTPM
  • amygdala: 2.7 nTPM
  • pons: 2.6 nTPM
  • hippocampal formation: 2.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CDC6.

Disease | AllUniProt

Conditions CDC6 is implicated in, by any mechanism.

Disease | ImmuneIEDB

Conditions an epitope on CDC6 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1
gnomAD pLI
0
gnomAD missense Z
0.61
DepMap mean gene effect
-1.36
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDC6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDC6 as an antibody target. Whether an autoantibody or antibody against CDC6 could matter depends on whether native CDC6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDC6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDC6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CDC6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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