Seroatlas · Human Serome Atlas

DNAH7

Dynein axonemal heavy chain 7

Also known as: DYH7_HUMAN, KIAA0944

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WXX0
Gene: DNAH7
Ensembl: ENSG00000118997
Chromosome: 2
Canonical length: 4024 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Vesicles,Cytosol,Mid piece,Annulus

OverviewNCBI Gene

DNAH7 is a component of the inner dynein arm of ciliary axonemes (Zhang et al., 2002 [PubMed 11877439]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

4024 residues, UniProt reviewed canonical sequence.

>Q8WXX0|DNAH7
     1  MSSEQDKSAS KEKSKKPVRF LPQLSMEKLA SKEKFKAPAR ALPQLSMVST KPHWQQAAPS
    61  FHLSVKQDDE SPEPFSVKNE QSHAEYMERF GKKGKLPHQV DDSYVGPSTS KSKGKSPHKE
   121  RENFRSTLVN VIMQQDADLD SAVPDGSTIP KPTASAIEKD ILRYYYYIHH GIDTDHVAPM
   181  EDSWLEHVLD LVPQHLKVFT DSIVTLSDEM REDYLLSVRK SIVDFVLKDP REKGDDKKTD
   241  ELPAHRAEME ILPKPWRKSF LAASSYIRDH LNAMNPTMLA VLDLWHTNFK KLRLVDIKEF
   301  HNCQDALELS SFQNIIMRHM DSAKETLLKM WFPEVQNIYY QGNKKKQLPT GDSSAKLESF
   361  FNCAAALMTL QLQDLTLVSM QDFTDLIAQP PDSVRAFEHP GFIMRLILDN DTIKFEPELS
   421  DYIDIFLNVY DVMIKAVSFV PRVETKLYSK WESKSKPTTL KPIILNEIVD AHKEKIKEVI
   481  MKESVAPTEH LRLYDKYDFL ITRKAERDVD NFLAENHSYE KIIDEICKYQ KLIEEIQYTS
   541  IKTIRLGMFE MHCEELIRAL VKRADIICGK LLAKMFRDHQ EVNTRLCDEF ERIAEKALST
   601  PPNTAELMEM KAYIQKVEVT DMIELEQRLV DSKNCLAFLI EYVNFSPADM RLNNSVFQWY
   661  GRMGEIFEEH RKIIKEKIEQ YQEGLKLRCE RFVEELESYA KQSEEFYSFG DLQDVQRYLK
   721  KAQILNGKLD LAADKIEQFN AEEEAFGWLP SVYPQRKKIQ DGLNPYLRLY ETAVEFSSNY
   781  RAWTEGPYHK VNPDQVEADI GNYWRGLYKL EKTFHDSPYA LAMTKKVRSK VEDFKQHIPL
   841  IQVICNPGLR PRHWEAMSAI VGYPLQPSDD STVSSFLDMN LEPYIDRFEG ISEAASKEYS
   901  LEKAMEKMIT EWDAVEFVIH SYRETGTFIL ASVDEIQMLL DDHIIKTQTM RGSPFIKPYE
   961  KQMREWEGKL LLLQEILDEW LKVQATWLYL EPIFSSPDIM SQMPEEGRRF TAVDKTWRDI
  1021  MRSVMQDKHV LTVVTIDRML ERLKKSNELL ELILKGLNEY LEKKRLFFPR FFFLSNDELL
  1081  EILSETKDPT RVQPHLKKCF EGIAKVEFTE TLDITHMKSS EGEVVELIEI ISTAKARGQV
  1141  EKWLVELERV MINSIHKVTG DATFAYTKYE RINWVRDWPG QTVLCVSQIF WTKEVQTAIP
  1201  MGIKALEQYL KTCNRQIDDI VTLVRGKLSM QNRVTLGALV VLDVHARDVL SSLVKKNISD
  1261  DSDFEWLSQL RYYWQENHLE TKMINAGLRY GYEYLGNSPR LVITPLTDRC YRTLFGALHL
  1321  HLGGAPEGPA GTGKTETTKD LAKAVAKQCV VFNCSDGLDY LALGKFFKGL LSCGAWACFD
  1381  EFNRIDLEVL SVVAQQILTI QRGINAGADI LMFEGTELKL DPTCAVFITM NPGYAGRSEL
  1441  PDNLKALFRT VAMMVPDYAM IAEIVLYSCG FVTARPLSVK IVATYRLCSE QLSSQHHYDY
  1501  GMRAVKSVLT AAGNLKLKYP NENEEILLLR SIIDVNLPKF LSHDLPLFEG ITSDLFPGVK
  1561  LPKPDYNDLL AAIKDNCASM NLQMTAFFSE KILQVYEMMI VRHGFMIVGE PFGGKTSAYR
  1621  VLAGALNDIC EKGLMEENKV QITVLNPKSV TMGQLYGQFD SVSHEWSDGV LAVSFRAFAS
  1681  SVTPDRKWLI FDGPVDAVWI ENMNTVLDDN KKLCLMSGEI IQMSPQMNLI FEPMDLEVAS
  1741  PATVSRCGMI YMEPHMLGWR PLMLSWVNLL PASVSVIQKE FIMGLFDRMV PVSVEFIRKH
  1801  TKELSPTSDT NLVRSLMNLI DCFMDDFADE VKLKERNDRE TYSLLEGIFL FSLIWSVGAS
  1861  CTDDDRLKFN KILRELMESP ISDRTRNTFK LQSGTEQTSS KALTVPFPEK GTIYDYQFVT
  1921  EGIGKWEPWI KKLKEAPPIP KDVMFNEIIV PTLDTIRYSA LMELLTTHQK PSIFVGPTGT
  1981  GKSVYITNFL LNQLNKEIYK PLLINFSAQT TAAQTQNIVM SKLDKRRKGV FGPPLGKRMV
  2041  VFVDDVNMPA REVYGAQPPI ELLRQWLDHW NWYDLKDCSM IKLVDIQIMC AMGPPGGGRN
  2101  PVTPRYMRHF NIITINEFSD KSMYTIFSRI LTWHLEICYK FPDEFLDLTT QIVNGTMTLY
  2161  KEAMKNLLPT PAKSHYLFNL RDFSRVIQGV CLSRPETTET TEVIKRLWVH EVLRVYYDRL
  2221  LDNTDRSWLI NYIQEILRNY MYEDFHELFQ RLDFDNDGMV EADDLRSLMF CDFHDPKRED
  2281  TNYREIADVD NLRMIVEIHL EEYNNISKKP MNLVLFRFAI EHISRISRIL KQPRSHALLV
  2341  GVGGSGRQSV TRLAAHMADY SVFQVEISKG YDTTEWHEDL KVILRKCAEG EMQGVFLFTD
  2401  TQIKEESFLE DVSNLLNAGE IPNLFALDEK QEICDKMRQL DRQRDKTKQT DGSPIALFNM
  2461  FIDHCRSQLH VVLAMSPIGD AFRNRLRKFP ALVNCCTIDW FQSWPEDALQ AVASRFLEEI
  2521  EMSEEIRDGC IDMCKSFHTS TIDLSKSFFV ELQRYNYVTP TSYLELISTF KLLLEKKRSE
  2581  VMKMKKRYEV GLEKLDSASS QVATMQMELE ALHPQLKVAS KEVDEMMIMI EKESVEVAKT
  2641  EKIVKADETI ANEQAMASKA IKDECDADLA GALPILESAL AALDTLTAQD ITVVKSMKSP
  2701  PAGVKLVMEA ICILKGIKAD KIPDPTGSGK KIEDFWGPAK RLLGDMRFLQ SLHEYDKDNI
  2761  PPAYMNIIRK NYIPNPDFVP EKIRNASTAA EGLCKWVIAM DSYDKVAKIV APKKIKLAAA
  2821  EGELKIAMDG LRKKQAALKE VQDKLARLQD TLELNKQKKA DLENQVDLCS KKLERAEQLI
  2881  GGLGGEKTRW SHTALELGQL YINLTGDILI SSGVVAYLGA FTSTYRQNQT KEWTTLCKGR
  2941  DIPCSDDCSL MGTLGEAVTI RTWNIAGLPS DSFSIDNGII IMNARRWPLM IDPQSQANKW
  3001  IKNMEKANSL YVIKLSEPDY VRTLENCIQF GTPVLLENVG EELDPILEPL LLKQTFKQGG
  3061  STCIRLGDST IEYAPDFRFY ITTKLRNPHY LPETSVKVTL LNFMITPEGM QDQLLGIVVA
  3121  QERPDLEEEK QALILQGAEN KRQLKEIEDK ILEVLSSSEG NILEDETAIK ILSSSKALAN
  3181  EISQKQEVAE ETEKKIDTTR MGYRPIAIHS SILFFSLADL ANIEPMYQYS LTWFINLFIL
  3241  SIENSEKSEI LAKRLQILKD HFTYSLYVNV CRSLFEKDKL LFSFCLTINL LLHERAINKA
  3301  EWRFLLTGGI GLDNPYANLC TWLPQKSWDE ICRLDDLPAF KTIRREFMRL KDGWKKVYDS
  3361  LEPHHEVFPE EWEDKANEFQ RMLIIRCLRP DKVIPMLQEF IINRLGRAFI EPPPFDLAKA
  3421  FGDSNCCAPL IFVLSPGADP MAALLKFADD QGYGGSKLSS LSLGQGQGPI AMKMLEKAVK
  3481  EGTWVVLQNC HLATSWMPTL EKVCEELSPE STHPDFRMWL TSYPSPNFPV SVLQNGVKMT
  3541  NEAPKGLRAN IIRSYLMDPI SDPEFFGSCK KPEEFKKLLY GLCFFHALVQ ERRKFGPLGW
  3601  NIPYEFNETD LRISVQQLHM FLNQYEELPY EALRYMTGEC NYGGRVTDDW DRRTLRSILN
  3661  KFFNPELVEN SDYKFDSSGI YFVPPSGDHK SYIEYTKTLP LTPAPEIFGM NANADITKDQ
  3721  SETQLLFDNI LLTQSRSAGA GAKSSDEVVN EVASDILGKL PNNFDIEAAM RRYPTTYTQS
  3781  MNTVLVQEMG RFNKLLKTIR DSCVNIQKAI KGLAVMSTDL EEVVSSILNV KIPEMWMGKS
  3841  YPSLKPLGSY VNDFLARLKF LQQWYEVGPP PVFWLSGFFF TQAFLTGAQQ NYARKYTIPI
  3901  DLLGFDYEVM EDKEYKHPPE DGVFIHGLFL DGASWNRKIK KLAESHPKIL YDTVPVMWLK
  3961  PCKRADIPKR PSYVAPLYKT SERRGVLSTT GHSTNFVIAM TLPSDQPKEH WIGRGVALLC
  4021  QLNS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DNAH7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 20 nTPM
testis: 10 nTPM
fallopian tube: 9.2 nTPM
basal ganglia: 8.7 nTPM
retina: 8.3 nTPM
pituitary gland: 7 nTPM

Single-cell type

ependymal cells: 1,864 nCPM
respiratory ciliated cells: 1,362 nCPM
choroid plexus epithelial cells: 1,119 nCPM
endometrial ciliated cells: 860 nCPM
fallopian tube ciliated cells: 738 nCPM
epididymal efferent duct ciliated cells: 577 nCPM

Immune cell

plasmacytoid DC: 0.3 nTPM
neutrophil: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

choroid plexus: 62 nTPM
midbrain: 26 nTPM
medulla oblongata: 20 nTPM
hypothalamus: 17 nTPM
cerebral cortex: 17 nTPM
amygdala: 15 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DNAH7.

Disease | AllUniProt

Conditions DNAH7 is implicated in, by any mechanism.

Ciliary dyskinesia, primary, 50 (CILD50) MIM:620356

Disease | GeneticClinVar

16 pathogenic / likely-pathogenic of 841 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Ciliary dyskinesia, primary, 50
Abnormal muscle tone
Seizure
Hypoplasia of the corpus callosum
Abnormal basal ganglia morphology

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.84
gnomAD pLI: 0
gnomAD missense Z: -1.09
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DNAH7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TBC1D21

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DNAH7 as an antibody target. Whether an autoantibody or antibody against DNAH7 could matter depends on whether native DNAH7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DNAH7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DNAH7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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