NOA1

Protein identityUniProt · HPA

UniProt accession

Q8NC60

Gene

NOA1

Ensembl

ENSG00000084092

Chromosome

4

Canonical length

698 aa

Protein class

Predicted intracellular proteins

Subcellular location

Mitochondria

Quaternary structure

Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a nuclear-encoded GTPase that functions in the mitochondrion. Upon translation, this protein is imported into the nucleus and then into the nucleolus before being exported to the mitochondrion. The encoded protein is required for oxygen-dependent regulation of mitochondrial respiratory complexes and for mitochondrial protein synthesis. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

698 residues, UniProt reviewed canonical sequence.

>Q8NC60|NOA1
     1  MLPARLPFRL LSLFLRGSAP TAARHGLREP LLERRCAAAS SFQHSSSLGR ELPYDPVDTE
    61  GFGEGGDMQE RFLFPEYILD PEPQPTREKQ LQELQQQQEE EERQRQQRRE ERRQQNLRAR
   121  SREHPVVGHP DPALPPSGVN CSGCGAELHC QDAGVPGYLP REKFLRTAEA DGGLARTVCQ
   181  RCWLLSHHRR ALRLQVSREQ YLELVSAALR RPGPSLVLYM VDLLDLPDAL LPDLPALVGP
   241  KQLIVLGNKV DLLPQDAPGY RQRLRERLWE DCARAGLLLA PGHQGPQRPV KDEPQDGENP
   301  NPPNWSRTVV RDVRLISAKT GYGVEELISA LQRSWRYRGD VYLVGATNAG KSTLFNTLLE
   361  SDYCTAKGSE AIDRATISPW PGTTLNLLKF PICNPTPYRM FKRHQRLKKD STQAEEDLSE
   421  QEQNQLNVLK KHGYVVGRVG RTFLYSEEQK DNIPFEFDAD SLAFDMENDP VMGTHKSTKQ
   481  VELTAQDVKD AHWFYDTPGI TKENCILNLL TEKEVNIVLP TQSIVPRTFV LKPGMVLFLG
   541  AIGRIDFLQG NQSAWFTVVA SNILPVHITS LDRADALYQK HAGHTLLQIP MGGKERMAGF
   601  PPLVAEDIML KEGLGASEAV ADIKFSSAGW VSVTPNFKDR LHLRGYTPEG TVLTVRPPLL
   661  PYIVNIKGQR IKKSVAYKTK KPPSLMYNVR KKKGKINV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NOA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.36

Highest tissue expression

35 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.74

gnomAD pLI

0

gnomAD missense Z

0.11

DepMap mean gene effect

-0.25

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• apoptotic process
• mitochondrial ribosome assembly
• mitochondrial small ribosomal subunit assembly
• mitochondrion organization

Molecular functions

• GTP binding
• RNA binding
• RNA folding chaperone

Cellular components

• mitochondrial inner membrane
• mitochondrial matrix
• mitochondrion

Protein domainsUniProt · Pfam · InterPro

• GTP binding domain
• P-loop containing nucleoside triphosphate hydrolase
• Circularly permuted (CP)-type guanine nucleotide-binding (G) domain
• 50S ribosome-binding GTPase
• NOA1/YqeH-like, C-terminal domain
• Mitochondrial translation and respiration regulator
• YqeH-like, C-terminal

KeywordsUniProt

• Apoptosis
• GTP-binding
• Membrane
• Mitochondrion
• Mitochondrion inner membrane
• Nucleotide-binding
• Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of NOA1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• DAP3
• MRPL12
• MRPS27
• LIN28A
• MRPS26