KIF26A

Protein identityUniProt · HPA

UniProt accession

Q9ULI4

Gene

KIF26A

Ensembl

ENSG00000066735

Chromosome

14

Canonical length

1882 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Plasma membrane,Cytosol,Connecting piece,Flagellar centriole

OverviewNCBI Gene

Predicted to enable microtubule binding activity. Involved in cerebral cortex development; regulation of neuron migration; and regulation of neuron projection development. Predicted to be located in cytosol. Implicated in complex cortical dysplasia with other brain malformations. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1882 residues, UniProt reviewed canonical sequence.

>Q9ULI4|KIF26A
     1  MVGRGVPLCA AQPAVAEGGP AREPPPLLEV SPRKRLPAGP DQDPCGSRPA PEGAGAGPEQ
    61  GHSAGGGGWC RHCHTKLVEL KRQAWKLVSG PGTTLRDPCL SALLLDKLPA PGALPACRPE
   121  AERRCDVCAT HLQQLTREAM HLLQAPASHE DLDAPHGGPS LAPPSTTTSS RDTPGPAGPA
   181  GRQPGRAGPD RTKGLAWSPG PSVQVSVAPA GLGGALSTVT IQAQQCLEGM WSVSRVNSFL
   241  PPACLAEAAV AAVAVADTVR ECPPVAGPDG LSKAWGRGGV CTSALVTPTP GSVGGSTGPS
   301  AAASFFIRAM QKLSLASKRK KPHPPPPPAT RGTSTYPTDF SGVLQLWPPP APPCLLRAAS
   361  KTKDNPGSIG KVKVMLRIWP AQGAQRSAEA MSFLKVDPRK KQVILYDPAA GPPGSAGPRR
   421  AATAAVPKMF AFDAVFPQDS EQAEVCSGTV ADVLQSVVSG ADGCIFSFGH MSLGKSYTMI
   481  GKDSSPQSLG IVPCAISWLF RLIEERRERT GTRFSVRVSA VEVCGRDQSL RDLLAEVAPG
   541  SLQDTQSPGV YLREDPVCGA QLQNQSELRA PTAEKAAFYL DAALAARSTS RAGCGEDARR
   601  SSHMLFTLHV YQYRMEKCGR GGMSGGRSRL HLIDLGSCEA AAGRAGEAAG GPLCLSLSAL
   661  GSVILALVNG AKHVPYRDHR LTMLLRESLA TAGCRTTMIA HVSDAPAQHA ETLSTVQLAA
   721  RIHRLRRKKA KYASSSSGGE SSCEEGRARR PPHLRPFHPR TVALDPDRTP PCLPGDPDYS
   781  SSSEQSCDTV IYVGPGGAAL SDRELTDNEG PPDFVPIIPA LSRHRPSKGP RDADHFRCST
   841  FAELQERLEC MDGNEGPSGG PGGTDGAQAS PARGGRKPSP PEAASPRKAV GTPMAASTPR
   901  GSSGPDTHQG TPEPCKAIVW GDQREDSSAW PELLVPEKAA VSGGRRPLPS PAPPPPQLLE
   961  ACRAPEEPGG GGTDGVARTP PVGMSGQVAG SPMLPGATCP RLAAGSRCPE RGLLTTTVTL
  1021  QRPVELNGED ELVFTVVEEL SLGALAGAGR PTSLASFDSD CSLRALASGS RPVSIISSIN
  1081  DEFDAYTSQA PEGGPLEGAA WAGSSHGSSI SSWLSEVSVC TADSRDPTPQ PRFSPDSLAG
  1141  LDPGGPPALD GSLGDGSSGF LGPDRPDSPG PTWGPCPGEV AAVAPSRPGR EPQAGPSRWA
  1201  SAAQTIHSSL PRKPRTASAT TRVGCARLGQ SPPGRGGLFE DPWLLRVGEC DTQAASAGRA
  1261  PSPTLGSPRL PEAQVMLACA QRVVDGCEVA ARAARRPEAV ARIPPLRRGA TTLGVTTPAV
  1321  SWGDAPTEVV ACSGSLKASP TSKKGLAPKA GFLPRPSGAA PPAPPTRKSS LEQRSSPASA
  1381  PPHAVNPARV GAAAVLRGEE EPRPSSRADH SVPRATSSLK ARASKVEAAH RLAGHASLER
  1441  YEGLAHSSSK GREAPGRPPR AVPKLGVPPS SPTHGPAPAC RSGAAKAVGA PKPPVGGGKG
  1501  RGLVAGGSRA LGPSVKLSTA SVTGRSPGGP VAGPRAAPRA GPSVGAKAGR GTVMGTKQAL
  1561  RAAHSRVHEL SASGAPGRGG SSWGSADSDS GHDSGVNVGE ERPPTGPALP SPYSKVTAPR
  1621  RPQRYSSGHG SDNSSVLSGE LPPAMGRTAL FHHSGGSSGY ESLRRDSEAT GSASSAPDSM
  1681  SESGAASPGA RTRSLKSPKK RATGLQRRRL IPAPLPDTTA LGRKPSLPGQ WVDLPPPLAG
  1741  SLKEPFEIKV YEIDDVERLQ RPRPTPREAP TQGLACVSTR LRLAERRQQR LREVQAKHKH
  1801  LCEELAETQG RLMLEPGRWL EQFEVDPELE PESAEYLAAL ERATAALEQC VNLCKAHVMM
  1861  VTCFDISVAA SAAIPGPQEV DV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIF26A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.59

Highest tissue expression

5.6 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KIF26A.

Disease | AllUniProt

Conditions KIF26A is implicated in, by any mechanism.

• Cortical dysplasia, complex, with other brain malformations 11 (CDCBM11) MIM:620156

Disease | GeneticClinVar

11 pathogenic / likely-pathogenic of 590 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Cortical dysplasia, complex, with other brain malformations 11

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.47

gnomAD pLI

0

gnomAD missense Z

0.09

DepMap mean gene effect

-0.02

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cerebral cortex development
• enteric nervous system development
• negative regulation of signal transduction
• regulation of cell growth by extracellular stimulus
• regulation of neuron migration
• regulation of neuron projection development

Molecular functions

• ATP binding
• microtubule binding

Cellular components

• cytosol
• microtubule

Protein domainsUniProt · Pfam · InterPro

• Kinesin motor domain
• P-loop containing nucleoside triphosphate hydrolase
• Kinesin-like protein
• Kinesin motor domain superfamily
• Kinesin-like protein KIF26A/B, helical domain
• Kinesin motor domain
• Kinesin-like protein KIF26A/B, tri-helical

KeywordsUniProt

• ATP-binding
• Coiled coil
• Cytoplasm
• Cytoskeleton
• Microtubule
• Motor protein
• Nucleotide-binding
• Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of KIF26A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• GRB2