Seroatlas · Human Serome Atlas

SLFN5

Schlafen family member 5

Also known as: MGC19764, SLFN5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q08AF3
Gene: SLFN5
Ensembl: ENSG00000166750
Chromosome: 17
Canonical length: 891 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

Predicted to enable ATP binding activity. Predicted to be involved in cell differentiation. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

891 residues, UniProt reviewed canonical sequence.

>Q08AF3|SLFN5
     1  MSLRIDVDTN FPECVVDAGK VTLGTQQRQE MDPRLREKQN EIILRAVCAL LNSGGGIIKA
    61  EIENKGYNYE RHGVGLDVPP IFRSHLDKMQ KENHFLIFVK SWNTEAGVPL ATLCSNLYHR
   121  ERTSTDVMDS QEALAFLKCR TQTPTNINVS NSLGPQAAQG SVQYEGNINV SAAALFDRKR
   181  LQYLEKLNLP ESTHVEFVMF STDVSHCVKD RLPKCVSAFA NTEGGYVFFG VHDETCQVIG
   241  CEKEKIDLTS LRASIDGCIK KLPVHHFCTQ RPEIKYVLNF LEVHDKGALR GYVCAIKVEK
   301  FCCAVFAKVP SSWQVKDNRV RQLPTREWTA WMMEADPDLS RCPEMVLQLS LSSATPRSKP
   361  VCIHKNSECL KEQQKRYFPV FSDRVVYTPE SLYKELFSQH KGLRDLINTE MRPFSQGILI
   421  FSQSWAVDLG LQEKQGVICD ALLISQNNTP ILYTIFSKWD AGCKGYSMIV AYSLKQKLVN
   481  KGGYTGRLCI TPLVCVLNSD RKAQSVYSSY LQIYPESYNF MTPQHMEALL QSLVIVLLGF
   541  KSFLSEELGS EVLNLLTNKQ YELLSKNLRK TRELFVHGLP GSGKTILALR IMEKIRNVFH
   601  CEPANILYIC ENQPLKKLVS FSKKNICQPV TRKTFMKNNF EHIQHIIIDD AQNFRTEDGD
   661  WYGKAKFITQ TARDGPGVLW IFLDYFQTYH LSCSGLPPPS DQYPREEINR VVRNAGPIAN
   721  YLQQVMQEAR QNPPPNLPPG SLVMLYEPKW AQGVPGNLEI IEDLNLEEIL IYVANKCRFL
   781  LRNGYSPKDI AVLFTKASEV EKYKDRLLTA MRKRKLSQLH EESDLLLQIG DASDVLTDHI
   841  VLDSVCRFSG LERNIVFGIN PGVAPPAGAY NLLLCLASRA KRHLYILKAS V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLFN5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

thymus: 38 nTPM
lymph node: 30 nTPM
tonsil: 27 nTPM
spleen: 24 nTPM
appendix: 23 nTPM
lung: 20 nTPM

Single-cell type

nk-cells: 176 nCPM
t-cells: 163 nCPM
fallopian tube ciliated cells: 144 nCPM
salivary ionocytes: 130 nCPM
vascular endothelial cells: 124 nCPM
fallopian secretory cells: 124 nCPM

Immune cell

T-reg: 69 nTPM
NK-cell: 42 nTPM
naive CD4 T-cell: 38 nTPM
naive CD8 T-cell: 31 nTPM
memory CD4 T-cell: 31 nTPM
MAIT T-cell: 31 nTPM

Brain region

medulla oblongata: 18 nTPM
white matter: 17 nTPM
spinal cord: 15 nTPM
pons: 13 nTPM
choroid plexus: 13 nTPM
thalamus: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.36
gnomAD pLI: 0
gnomAD missense Z: 0.34
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLFN5 as an antibody target. Whether an autoantibody or antibody against SLFN5 could matter depends on whether native SLFN5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLFN5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLFN5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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