Seroatlas · Human Serome Atlas

WSCD2

Sialate:O-sulfotransferase 2

Also known as: KIAA0789, WSCD2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2TBF2
Gene: WSCD2
Ensembl: ENSG00000075035
Chromosome: 12
Canonical length: 565 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable sulfotransferase activity. Predicted to be located in Golgi membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

565 residues, UniProt reviewed canonical sequence.

>Q2TBF2|WSCD2
     1  MAKLWFKFQR YFRRKPVRFF TFLALYLTAG SLVFLHSGFV GQPAVSGNQA NPAAAGGPAE
    61  GAELSFLGDM HLGRGFRDTG EASSIARRYG PWFKGKDGNE RAKLGDYGGA WSRALKGRVV
   121  REKEEERAKY IGCYLDDTQS RALRGVSFFD YKKMTIFRCQ DNCAERGYLY GGLEFGAECY
   181  CGHKIQATNV SEAECDMECK GERGSVCGGA NRLSVYRLQL AQESARRYGS AVFRGCFRRP
   241  DNLSLALPVT AAMLNMSVDK CVDFCTEKEY PLAALAGTAC HCGFPTTRFP LHDREDEQLC
   301  AQKCSAEEFE SCGTPSYFIV YQTQVQDNRC MDRRFLPGKS KQLIALASFP GAGNTWARHL
   361  IELATGFYTG SYYFDGSLYN KGFKGERDHW RSGRTICIKT HESGQKEIEA FDAAILLIRN
   421  PYKALMAEFN RKYGGHIGFA AHAHWKGKEW PEFVRNYAPW WATHTLDWLK FGKKVLVVHF
   481  EDLKQDLFVQ LGRMVSLLGV AVREDRLLCV ESQKDGNFKR SGLRKLEYDP YTADMQKTIS
   541  AYIKMVDAAL KGRNLTGVPD DYYPR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WSCD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 105 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 105 nTPM
basal ganglia: 16 nTPM
thyroid gland: 16 nTPM
cerebral cortex: 15 nTPM
seminal vesicle: 13 nTPM
hippocampal formation: 11 nTPM

Single-cell type

retinal bipolar cells: 105 nCPM
retinal amacrine cells: 96 nCPM
brain excitatory neurons: 92 nCPM
brain inhibitory neurons: 65 nCPM
retinal horizontal cells: 54 nCPM
pituitary stem cells: 49 nCPM

Immune cell

T-reg: 0.5 nTPM
memory B-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebellum: 83 nTPM
hippocampal formation: 44 nTPM
basal ganglia: 36 nTPM
cerebral cortex: 35 nTPM
hypothalamus: 26 nTPM
white matter: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.39
gnomAD pLI: 0.78
gnomAD missense Z: 1.39
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

sulfotransferase activity

Cellular components

Golgi membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WSCD2 as an antibody target. Whether an autoantibody or antibody against WSCD2 could matter depends on whether native WSCD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WSCD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WSCD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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